转录本相关分析鉴定与铁代谢相关的植物新基因:下一步是什么?

IF 3.6 3区 生物学 Q1 PLANT SCIENCES
Plant Biology Pub Date : 2025-07-02 DOI:10.1111/plb.70068
I Murgia, P Morandini
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引用次数: 0

摘要

由于“拟南芥基因组计划”(Arabidopsis genome Initiative),以及来自世界各地科学家的贡献,拟南芥是第一个被完全测序的植物基因组,大约在25年前。这一里程碑在植物科学界受到了热烈欢迎,因为它在对生物过程的精细理解方面具有潜力。从那时起,来自其他植物物种的数十个基因组,包括主要作物,已经被完全测序和注释。然而,对于每一个已测序的植物基因组,仍有一些基因缺乏任何指定的分子活性,或者它们在体内的生物学功能尚未明确。在这里,我们展示了转录相关分析(TCA)如何使我们能够识别参与植物铁(Fe)代谢的新的候选基因,并对这些预测进行了实验验证。这种生物信息学方法也被应用于其他植物代谢途径。并对TCA在植物铁及其他研究中的应用提出了建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Transcript correlation analysis for the identification of novel plant genes involved in iron metabolism and beyond: what next?

Arabidopsis thaliana was the first plant genome to be fully sequenced, almost a quarter of a century ago, thanks to The Arabidopsis Genome Initiative, with contributions from scientists worldwide. This milestone was welcomed enthusiastically within the plant science community, for its potential in terms of fine understanding of biological processes. Since then, tens of genomes from other plant species, including staple crops, have been fully sequenced and annotated. However, for each sequenced plant genome, several genes still lack any assigned molecular activity, or their biological in vivo function has not yet been clarified. Here we show how transcript correlation analysis (TCA) has allowed us to identify novel candidate genes involved in iron (Fe) metabolism in plants, together with experimental validation of such predictions. This bioinformatics approach has also been applied to other plant metabolic pathways. Suggestions for exploitation of TCA for research into plant Fe and beyond is discussed.

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来源期刊
Plant Biology
Plant Biology 生物-植物科学
CiteScore
8.20
自引率
2.60%
发文量
109
审稿时长
3 months
期刊介绍: Plant Biology is an international journal of broad scope bringing together the different subdisciplines, such as physiology, molecular biology, cell biology, development, genetics, systematics, ecology, evolution, ecophysiology, plant-microbe interactions, and mycology. Plant Biology publishes original problem-oriented full-length research papers, short research papers, and review articles. Discussion of hot topics and provocative opinion articles are published under the heading Acute Views. From a multidisciplinary perspective, Plant Biology will provide a platform for publication, information and debate, encompassing all areas which fall within the scope of plant science.
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