靶向脂质体和加速CRISPR系统用于细胞中miR-21的选择性成像。

IF 2.6 3区化学 Q2 CHEMISTRY, ANALYTICAL

Analytical Methods Pub Date : 2025-06-26 DOI:10.1039/D5AY00619H

Wenyue Zhang, Mengting Wu, Qingqing Zhang, Xibin Chen and Yingshu Guo

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引用次数: 0

摘要

本研究展示了一种针对MCF-7细胞内miR-21特异性反应的脂质体靶向和加速CRISPR策略。在MUC1适体修饰的帮助下实现了靶向。MnO2 NS可作为CRISPR系统的递送载体和加速器，最终实现miR-21的空间选择性成像。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Targeting liposomes and an accelerated CRISPR system for selective imaging of miR-21 in cells†

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Targeting liposomes and an accelerated CRISPR system for selective imaging of miR-21 in cells†

This study demonstrates a liposome-targeted and accelerated CRISPR strategy for specific response of miR-21 within MCF-7 cells. Targeting was achieved with the help of modification of the MUC1 aptamer. MnO₂ NS could be used as both a delivery vehicle and an accelerator for the CRISPR system, and finally to achieve spatially selective imaging of miR-21.

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