“通过肠道的治疗”：非胃肠道疾病的口服靶向给药（医疗保健材料，17/2025）

IF 9.6 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2025-07-04 DOI:10.1002/adhm.202570105

Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta

{"title":"“通过肠道的治疗”：非胃肠道疾病的口服靶向给药（医疗保健材料，17/2025）","authors":"Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta","doi":"10.1002/adhm.202570105","DOIUrl":null,"url":null,"abstract":"<p><b>Targeted Therapies Through Gut</b></p><p>Oral drug delivery holds promise for treating non-gastrointestinal diseases but faces barriers like intestinal permeability and low bioavailability. Targeted nanoparticles using ligands like chitosan, butyrate, and yeast capsules improve absorption and release. Despite progress in crossing the intestinal barrier to treat conditions like cancer and fibrosis, challenges in stability and efficacy remain key considerations. More details can be found in article 2403162 by Hang Thu Ta and co-workers.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"14 17","pages":""},"PeriodicalIF":9.6000,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202570105","citationCount":"0","resultStr":"{\"title\":\"“Therapies Through Gut:” Targeted Drug Delivery for Non-Gastrointestinal Diseases by Oral Administration (Adv. Healthcare Mater. 17/2025)\",\"authors\":\"Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta\",\"doi\":\"10.1002/adhm.202570105\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><b>Targeted Therapies Through Gut</b></p><p>Oral drug delivery holds promise for treating non-gastrointestinal diseases but faces barriers like intestinal permeability and low bioavailability. Targeted nanoparticles using ligands like chitosan, butyrate, and yeast capsules improve absorption and release. Despite progress in crossing the intestinal barrier to treat conditions like cancer and fibrosis, challenges in stability and efficacy remain key considerations. More details can be found in article 2403162 by Hang Thu Ta and co-workers.\\n\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":113,\"journal\":{\"name\":\"Advanced Healthcare Materials\",\"volume\":\"14 17\",\"pages\":\"\"},\"PeriodicalIF\":9.6000,\"publicationDate\":\"2025-07-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202570105\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Healthcare Materials\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/adhm.202570105\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Healthcare Materials","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/adhm.202570105","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}

引用次数: 0

摘要

通过肠道给药的靶向治疗有望治疗非胃肠道疾病，但面临肠道通透性和低生物利用度等障碍。使用壳聚糖、丁酸盐和酵母胶囊等配体的靶向纳米颗粒可以改善吸收和释放。尽管在跨越肠道屏障治疗癌症和纤维化等疾病方面取得了进展，但稳定性和有效性方面的挑战仍然是关键考虑因素。更多的细节可以在Hang Thu Ta和同事的文章2403162中找到。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

“Therapies Through Gut:” Targeted Drug Delivery for Non-Gastrointestinal Diseases by Oral Administration (Adv. Healthcare Mater. 17/2025)

查看原文本刊更多论文

“Therapies Through Gut:” Targeted Drug Delivery for Non-Gastrointestinal Diseases by Oral Administration (Adv. Healthcare Mater. 17/2025)

Targeted Therapies Through Gut

Oral drug delivery holds promise for treating non-gastrointestinal diseases but faces barriers like intestinal permeability and low bioavailability. Targeted nanoparticles using ligands like chitosan, butyrate, and yeast capsules improve absorption and release. Despite progress in crossing the intestinal barrier to treat conditions like cancer and fibrosis, challenges in stability and efficacy remain key considerations. More details can be found in article 2403162 by Hang Thu Ta and co-workers.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.