{"title":"穴位埋线对哮喘患者改善睡眠质量和控制哮喘症状的联合作用及机制研究","authors":"Zhihong Shi, Wulanqiqige, Qing Quan, Narentuya Zhao, Yanan Wang, Xiaohong Bai, Xiaoyan Hu","doi":"10.1111/crj.70091","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Asthma is a chronic airway inflammatory disease that significantly affects patients' quality of life and mental health. This study aims to compare the differences between acupoint embedding auxiliary therapy and traditional auxiliary therapy in asthma control, immune response, sleep quality, and quality of life, as well as evaluate their therapeutic effects on patients with asthma.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A retrospective analysis of 300 patients with asthma was conducted, divided into acupoint catgut embedding and conventional treatment groups. Key assessments included asthma control (ACQ score), exacerbation frequency, HADS, PSQI, and SF-36 for quality of life. Immune markers (IgE, eosinophil count, IL-4, IL-5, IL-10) were measured. Univariate and multivariate logistic regression analyses and ROC curves were used to identify predictors of asthma control and sleep quality. Stratified analysis evaluated differences by asthma severity.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The acupoint catgut embedding group showed significant improvements in asthma control (<i>p</i> < 0.001), exacerbation frequency (<i>p</i> < 0.05), and anxiety and depression (<i>p</i> = 0.0359) compared to the conventional treatment group. IgE (<i>p</i> = 0.00656), eosinophil count (<i>p</i> = 0.0214), and IL-5 (<i>p</i> = 0.0187) were significantly lower, while IL-10 (<i>p</i> = 0.0226) was higher in the acupoint group. Sleep quality (PSQI score, <i>p</i> = 0.0117) and deep sleep (NREM 3, <i>p</i> < 0.05) improved. Asthma severity (<i>p</i> < 0.001) and treatment method (<i>p</i> < 0.001) were significant predictors of outcomes, with model 2 (AUC = 0.731) outperforming model 1 (AUC = 0.649). Stratified analysis showed acupoint therapy was more effective in intermittent and mild asthma.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>As an auxiliary treatment, acupoint embedding therapy has shown a good effect in improving the sleep quality of patients with asthma and controlling asthma symptoms, especially in patients with mild-to-moderate asthma.</p>\n </section>\n </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 7","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70091","citationCount":"0","resultStr":"{\"title\":\"Study on the Combined Effects and Mechanisms of Acupoint Catgut Embedding in Improving Sleep Quality and Controlling Asthma Symptoms in Patients With Asthma\",\"authors\":\"Zhihong Shi, Wulanqiqige, Qing Quan, Narentuya Zhao, Yanan Wang, Xiaohong Bai, Xiaoyan Hu\",\"doi\":\"10.1111/crj.70091\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Asthma is a chronic airway inflammatory disease that significantly affects patients' quality of life and mental health. This study aims to compare the differences between acupoint embedding auxiliary therapy and traditional auxiliary therapy in asthma control, immune response, sleep quality, and quality of life, as well as evaluate their therapeutic effects on patients with asthma.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A retrospective analysis of 300 patients with asthma was conducted, divided into acupoint catgut embedding and conventional treatment groups. Key assessments included asthma control (ACQ score), exacerbation frequency, HADS, PSQI, and SF-36 for quality of life. Immune markers (IgE, eosinophil count, IL-4, IL-5, IL-10) were measured. Univariate and multivariate logistic regression analyses and ROC curves were used to identify predictors of asthma control and sleep quality. Stratified analysis evaluated differences by asthma severity.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The acupoint catgut embedding group showed significant improvements in asthma control (<i>p</i> < 0.001), exacerbation frequency (<i>p</i> < 0.05), and anxiety and depression (<i>p</i> = 0.0359) compared to the conventional treatment group. IgE (<i>p</i> = 0.00656), eosinophil count (<i>p</i> = 0.0214), and IL-5 (<i>p</i> = 0.0187) were significantly lower, while IL-10 (<i>p</i> = 0.0226) was higher in the acupoint group. Sleep quality (PSQI score, <i>p</i> = 0.0117) and deep sleep (NREM 3, <i>p</i> < 0.05) improved. Asthma severity (<i>p</i> < 0.001) and treatment method (<i>p</i> < 0.001) were significant predictors of outcomes, with model 2 (AUC = 0.731) outperforming model 1 (AUC = 0.649). Stratified analysis showed acupoint therapy was more effective in intermittent and mild asthma.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>As an auxiliary treatment, acupoint embedding therapy has shown a good effect in improving the sleep quality of patients with asthma and controlling asthma symptoms, especially in patients with mild-to-moderate asthma.</p>\\n </section>\\n </div>\",\"PeriodicalId\":55247,\"journal\":{\"name\":\"Clinical Respiratory Journal\",\"volume\":\"19 7\",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-07-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70091\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Respiratory Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/crj.70091\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Respiratory Journal","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/crj.70091","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
Study on the Combined Effects and Mechanisms of Acupoint Catgut Embedding in Improving Sleep Quality and Controlling Asthma Symptoms in Patients With Asthma
Background
Asthma is a chronic airway inflammatory disease that significantly affects patients' quality of life and mental health. This study aims to compare the differences between acupoint embedding auxiliary therapy and traditional auxiliary therapy in asthma control, immune response, sleep quality, and quality of life, as well as evaluate their therapeutic effects on patients with asthma.
Methods
A retrospective analysis of 300 patients with asthma was conducted, divided into acupoint catgut embedding and conventional treatment groups. Key assessments included asthma control (ACQ score), exacerbation frequency, HADS, PSQI, and SF-36 for quality of life. Immune markers (IgE, eosinophil count, IL-4, IL-5, IL-10) were measured. Univariate and multivariate logistic regression analyses and ROC curves were used to identify predictors of asthma control and sleep quality. Stratified analysis evaluated differences by asthma severity.
Results
The acupoint catgut embedding group showed significant improvements in asthma control (p < 0.001), exacerbation frequency (p < 0.05), and anxiety and depression (p = 0.0359) compared to the conventional treatment group. IgE (p = 0.00656), eosinophil count (p = 0.0214), and IL-5 (p = 0.0187) were significantly lower, while IL-10 (p = 0.0226) was higher in the acupoint group. Sleep quality (PSQI score, p = 0.0117) and deep sleep (NREM 3, p < 0.05) improved. Asthma severity (p < 0.001) and treatment method (p < 0.001) were significant predictors of outcomes, with model 2 (AUC = 0.731) outperforming model 1 (AUC = 0.649). Stratified analysis showed acupoint therapy was more effective in intermittent and mild asthma.
Conclusion
As an auxiliary treatment, acupoint embedding therapy has shown a good effect in improving the sleep quality of patients with asthma and controlling asthma symptoms, especially in patients with mild-to-moderate asthma.
期刊介绍：
Overview
Effective with the 2016 volume, this journal will be published in an online-only format.
Aims and Scope
The Clinical Respiratory Journal (CRJ) provides a forum for clinical research in all areas of respiratory medicine from clinical lung disease to basic research relevant to the clinic.
We publish original research, review articles, case studies, editorials and book reviews in all areas of clinical lung disease including:
Asthma
Allergy
COPD
Non-invasive ventilation
Sleep related breathing disorders
Interstitial lung diseases
Lung cancer
Clinical genetics
Rhinitis
Airway and lung infection
Epidemiology
Pediatrics
CRJ provides a fast-track service for selected Phase II and Phase III trial studies.
Keywords
Clinical Respiratory Journal, respiratory, pulmonary, medicine, clinical, lung disease,
Abstracting and Indexing Information
Academic Search (EBSCO Publishing)
Academic Search Alumni Edition (EBSCO Publishing)
Embase (Elsevier)
Health & Medical Collection (ProQuest)
Health Research Premium Collection (ProQuest)
HEED: Health Economic Evaluations Database (Wiley-Blackwell)
Hospital Premium Collection (ProQuest)
Journal Citation Reports/Science Edition (Clarivate Analytics)
MEDLINE/PubMed (NLM)
ProQuest Central (ProQuest)
Science Citation Index Expanded (Clarivate Analytics)
SCOPUS (Elsevier)
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