大戟萜类化合物及其抗炎治疗潜力

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-06-30 DOI:10.1016/j.fitote.2025.106725

Qin Yang , Yali Wang , Zhiqi Zhang , Ziyan Gao , Qianhui Liu , Hua Li , Lixia Chen

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引用次数: 0

摘要

从植物大戟（Euphorbia wallichii）中分离得到12个已知化合物和4个未描述的萜类化合物，包括wallbioid B(1)、wallingen A(8)、wallabielide B（13）和wallabiaid A（14）。通过一维和二维核磁共振、计算电子圆二色性（ECD）和质谱分析对这些化合物的结构和立体化学进行了评价。此外，我们还检测了这些分离化合物对lps诱导的小鼠单核巨噬细胞白血病细胞RAW264.7一氧化氮（NO）过量产生的抑制作用。代表性化合物10与ALB蛋白分子对接，预测其抗炎症作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Terpenoids from Euphorbia wallichii and their anti-inflammatory therapeutic potential

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Terpenoids from Euphorbia wallichii and their anti-inflammatory therapeutic potential

Twelve known compounds and four undescribed terpenoids, including wallbiaoid B (1), wallingen A (8), wallabielide B (13) and wallabiaid A (14) were isolated from the plant Euphorbia wallichii. The structure and stereochemistry of these compounds were evaluated by 1D and 2D NMR, calculated electronic circular dichroism (ECD) and mass spectrometry analysis. In addition, the inhibitory effect of all these isolated compounds on LPS-induced nitric oxide (NO) overproduction in mouse monocyte-macrophage leukemia cell RAW264.7 was determined. Representative compound 10 was molecularly docked with ALB protein to predict its efficacy against inflammation.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.