Qin Yang , Yali Wang , Zhiqi Zhang , Ziyan Gao , Qianhui Liu , Hua Li , Lixia Chen
{"title":"大戟萜类化合物及其抗炎治疗潜力","authors":"Qin Yang , Yali Wang , Zhiqi Zhang , Ziyan Gao , Qianhui Liu , Hua Li , Lixia Chen","doi":"10.1016/j.fitote.2025.106725","DOIUrl":null,"url":null,"abstract":"<div><div>Twelve known compounds and four undescribed terpenoids, including wallbiaoid B (<strong>1</strong>), wallingen A (<strong>8</strong>), wallabielide B (<strong>13</strong>) and wallabiaid A (<strong>14</strong>) were isolated from the plant <em>Euphorbia wallichii</em>. The structure and stereochemistry of these compounds were evaluated by 1D and 2D NMR, calculated electronic circular dichroism (ECD) and mass spectrometry analysis. In addition, the inhibitory effect of all these isolated compounds on LPS-induced nitric oxide (NO) overproduction in mouse monocyte-macrophage leukemia cell RAW264.7 was determined. Representative compound <strong>10</strong> was molecularly docked with ALB protein to predict its efficacy against inflammation.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"185 ","pages":"Article 106725"},"PeriodicalIF":2.5000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Terpenoids from Euphorbia wallichii and their anti-inflammatory therapeutic potential\",\"authors\":\"Qin Yang , Yali Wang , Zhiqi Zhang , Ziyan Gao , Qianhui Liu , Hua Li , Lixia Chen\",\"doi\":\"10.1016/j.fitote.2025.106725\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Twelve known compounds and four undescribed terpenoids, including wallbiaoid B (<strong>1</strong>), wallingen A (<strong>8</strong>), wallabielide B (<strong>13</strong>) and wallabiaid A (<strong>14</strong>) were isolated from the plant <em>Euphorbia wallichii</em>. The structure and stereochemistry of these compounds were evaluated by 1D and 2D NMR, calculated electronic circular dichroism (ECD) and mass spectrometry analysis. In addition, the inhibitory effect of all these isolated compounds on LPS-induced nitric oxide (NO) overproduction in mouse monocyte-macrophage leukemia cell RAW264.7 was determined. Representative compound <strong>10</strong> was molecularly docked with ALB protein to predict its efficacy against inflammation.</div></div>\",\"PeriodicalId\":12147,\"journal\":{\"name\":\"Fitoterapia\",\"volume\":\"185 \",\"pages\":\"Article 106725\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Fitoterapia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0367326X2500351X\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0367326X2500351X","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Terpenoids from Euphorbia wallichii and their anti-inflammatory therapeutic potential
Twelve known compounds and four undescribed terpenoids, including wallbiaoid B (1), wallingen A (8), wallabielide B (13) and wallabiaid A (14) were isolated from the plant Euphorbia wallichii. The structure and stereochemistry of these compounds were evaluated by 1D and 2D NMR, calculated electronic circular dichroism (ECD) and mass spectrometry analysis. In addition, the inhibitory effect of all these isolated compounds on LPS-induced nitric oxide (NO) overproduction in mouse monocyte-macrophage leukemia cell RAW264.7 was determined. Representative compound 10 was molecularly docked with ALB protein to predict its efficacy against inflammation.
期刊介绍:
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.