可吸入高岭土细长矿物颗粒的潜在毒性评价：来自纤维潜在毒性指数（FPTI）模型的见解

IF 5.8 2区地球科学 Q2 CHEMISTRY, PHYSICAL

Applied Clay Science Pub Date : 2025-07-03 DOI:10.1016/j.clay.2025.107917

Alessandro F. Gualtieri , Laurie Glossop , Daniele Malferrari , Elena Castellini , Magdalena Lassinantti Gualtieri , Miriam Hanuskova , Luca Nodari , Jordan Ogor , Riccardo Fantini

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引用次数: 0

摘要

高岭土是高岭土族的一员，具有理想的化学成分Al2(OH)4Si2O5⋅2H2O，具有从传统陶瓷到药物输送等广泛多样的工业应用。高岭土通常以细长矿物颗粒（emp）的形式出现，具有纳米大小的管状、圆柱形或纤维状。尽管有这些特点和广泛的用途，国际癌症研究机构（IARC）尚未评估高岭土的潜在致癌性。现有文献主要集中在药物环境下口服给药后的毒性，但研究结果仍不确定。在这项研究中，研究人员调查了来自新西兰北岛Matauri湾的一处市售高岭土，以进一步了解陶瓷工业中空气中纳米颗粒的潜在职业暴露。利用XRPD、TGA-DTA、XRF-WDS、BET、粒度分布、SEM、TEM、Mössbauer和UV-Vis光谱对样品进行了全面表征。这种多技术方法允许通过纤维潜在毒性指数（FPTI）模型来确定其毒性潜力，该模型在评估可呼吸性矿物纤维的危险性方面已经被证明是可靠的。结果表明，样品中高岭土含量约为90%，石英和方英石含量较少。高岭土纳米管是可呼吸的，但不是“受调节的纤维”，其FPTI值为1.92(0.10)，与非致癌矿物纤维相当，谨慎地表明，高岭土是一种低毒性的纳米材料。虽然这项研究的重点是来自一个特定地点的样品，但结果应被认为适用于任何采石场的高岭土样品；然而，应该指出的是，该矿床的高岭土含有可呼吸的石英和方石英，这是IARC第1组已知的人类致癌物。

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Evaluation of the potential toxicity of respirable halloysite elongate mineral particles: Insights from the Fibre Potential Toxicity Index (FPTI) model

Halloysite is a member of the kaolin group, with an ideal chemical composition of Al₂(OH)₄Si₂O₅⋅2H₂O, displaying wide and diverse industrial application spanning from traditional ceramics to drug delivery. Halloysite often occurs as elongate mineral particles (EMPs) with nanometer-size tubular, cylindrical or fibrous shape. Despite these features and its extensive use, the International Agency for Research on Cancer (IARC) has not yet evaluated halloysite for its potential carcinogenicity. Existing literature only focused on its toxicity following oral administration mostly in a pharmaceutical contexts, but findings remain inconclusive.

In this study, a commercially available halloysite from Matauri Bay (North Island, New Zealand) was investigated to provide further insight into potential occupational exposure to airborne nano-particles in the ceramic industry. A comprehensive characterization of the sample was performed using XRPD, TGA-DTA, XRF-WDS, BET, particle size distribution, SEM, TEM, Mössbauer and UV–Vis spectroscopies. This multi-technique approach permitted to determine its toxicity potential through the Fibre Potential Toxicity Index (FPTI) model, which had already proven robust in evaluating the hazardousness of respirable mineral fibres. Results indicated that the sample contains approximately 90 wt% halloysite, with minor quartz and cristobalite. Halloysite nanotubes are respirable but not “regulated fibres” with a FPTI value of 1.92(0.10), comparable to that of non-carcinogenic mineral fibres suggesting, with caution, that halloysite is a nanomaterial with low toxicity. Although the study focused on samples from a specific locality, the results should be considered applicable to halloysite samples from any quarry; nevertheless, it should be noted that halloysite from this deposit contains respirable quartz and cristobalite which are a IARC Group 1 known human carcinogens.

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来源期刊

Applied Clay Science 地学-矿物学

CiteScore

10.30

自引率

10.70%

发文量

289

审稿时长

39 days

期刊介绍： Applied Clay Science aims to be an international journal attracting high quality scientific papers on clays and clay minerals, including research papers, reviews, and technical notes. The journal covers typical subjects of Fundamental and Applied Clay Science such as: • Synthesis and purification • Structural, crystallographic and mineralogical properties of clays and clay minerals • Thermal properties of clays and clay minerals • Physico-chemical properties including i) surface and interface properties; ii) thermodynamic properties; iii) mechanical properties • Interaction with water, with polar and apolar molecules • Colloidal properties and rheology • Adsorption, Intercalation, Ionic exchange • Genesis and deposits of clay minerals • Geology and geochemistry of clays • Modification of clays and clay minerals properties by thermal and physical treatments • Modification by chemical treatments with organic and inorganic molecules(organoclays, pillared clays) • Modification by biological microorganisms. etc...