生物功能化3d打印PLA/PCL支架与鹿茸肽增强骨再生

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Letters Pub Date : 2025-06-27 DOI:10.1016/j.matlet.2025.138998

Changyu Liu , Yuchen Hong , Wen Ma , Renyi Cheng , Tao Xie , Peishen Deng , Chaofeng Liu , Jinjun Tian , Yanhua Xu

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引用次数: 0

摘要

结合机械强度和生物活性的支架在骨组织工程中是至关重要的。以聚乳酸（PLA）和聚己内酯（PCL）为原料，以4:6的比例加入鹿茸肽（VAP）促进成骨，通过三维（3D）打印制备了一种新型复合支架。PLA/PCL支架表现出平衡的刚度和柔韧性。体外持续释放VAP可显著促进细胞成骨分化。体内研究证实vap促进骨再生。这种PLA/PCL-VAP支架具有可定制的力学和骨诱导能力，在骨缺损修复方面显示出强大的前景。

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Biofunctionalized 3D-Printed PLA/PCL scaffolds with velvet antler peptides for enhanced bone regeneration

Scaffolds combining mechanical strength and bioactivity are vital for bone tissue engineering. We fabricated a novel composite scaffold via three-dimensional (3D) printing using polylactic acid (PLA) and polycaprolactone (PCL) at a 4:6 ratio, incorporated with velvet antler peptides (VAP) to enhance osteogenesis. The PLA/PCL scaffold demonstrated balanced stiffness and flexibility. In vitro, sustained VAP release significantly promoted osteogenic differentiation of cells. In vivo studies confirmed VAP-enhanced bone regeneration. This PLA/PCL-VAP scaffold exhibits tailorable mechanics and osteoinductive capacity, showing strong promise for bone defect repair.

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来源期刊

Materials Letters 工程技术-材料科学：综合

CiteScore

5.60

自引率

3.30%

发文量

1948

审稿时长

50 days

期刊介绍： Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials. Contributions include, but are not limited to, a variety of topics such as: • Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors • Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart • Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction • Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots. • Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing. • Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic • Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive