水溶性空腔体合成的无柱色谱方法。

IF 3.6 2区 化学 Q1 CHEMISTRY, ORGANIC
Gabriele Zirpoli,Manuel Petroselli
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引用次数: 0

摘要

本文报道了一种高效的合成方案,用于合成一个前所未有的间苯二酚[4]芳烃基水溶性分子容器库。这种方法的关键是四碘衍生物3,称为“关键碘空腔体”(KIC),它作为一个凹形支架,通过Sonogashira偶联合成深空腔体。本研究中描述的大多数深空腔都是在没有色谱过程的情况下合成的,这使得纯化速度更快,易于接近,更容易放大,同时也提供了与现有空腔在大小和形状方面不同的空腔。在D2O中报道了环癸烷作为模型客体的初步结合实验,而DFT计算证实了富勒烯衍生物如C60和C70的包封,突出了所提出的分子容器的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Column Chromatography-Free Protocol for the Synthesis of Water-Soluble Cavitands.
An efficient synthetic protocol for the synthesis of a library of unprecedented resorcin[4]arene-based water-soluble molecular containers is reported here. Key to this approach is the tetra-iodo derivative 3, named "Key Iodo Cavitand" (KIC), which acts as a concave-shaped scaffold for the synthesis of deep-cavitands via Sonogashira coupling. Most of the deep-cavitands described in this study are synthesized without chromatographic processes, leading to a faster purification, ready accessibility, and easier scale-up, while also offering a different cavity in terms of size and shape compared to the current ones. Preliminary binding experiments on cyclodecane as a model guest are reported in D2O, while DFT calculations confirm the encapsulation of fullerene derivatives such as C60 and C70, highlighting the potential of the proposed molecular containers.
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来源期刊
Journal of Organic Chemistry
Journal of Organic Chemistry 化学-有机化学
CiteScore
6.20
自引率
11.10%
发文量
1467
审稿时长
2 months
期刊介绍: Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.
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