解码大肠杆菌蛋白的分子编排：基因毒性装配线的结构洞察

IF 4.4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Structure Pub Date : 2025-07-03 DOI:10.1016/j.str.2025.06.001

Dandan Li, Zhijun Wang

引用次数: 0

摘要

模块化聚酮合成酶（PKS）和非核糖体肽合成酶（NRPS）途径的进化融合打开了任何一个系统单独无法进入的化学空间。在本期《结构》杂志中，Kim等人1展示了大肠杆菌素生物合成酶ClbC和ClbI的冷冻电镜（cro - em）结构，揭示了对PKS-NRPS机制的前所未有的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Decoding the molecular choreography of colibactin: Structural insights into a genotoxic assembly line

The evolutionary fusion of modular polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) pathways unlocks chemical space that is inaccessible to either system alone. In this issue of Structure, Kim et al.¹ present cryoelectron microscopy (cryo-EM) structures of the colibactin biosynthetic enzymes ClbC and ClbI that reveal unprecedented insights into PKS-NRPS mechanisms.

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来源期刊

Structure 生物-生化与分子生物学

CiteScore

8.90

自引率

1.80%

发文量

155

审稿时长

3-8 weeks

期刊介绍： Structure aims to publish papers of exceptional interest in the field of structural biology. The journal strives to be essential reading for structural biologists, as well as biologists and biochemists that are interested in macromolecular structure and function. Structure strongly encourages the submission of manuscripts that present structural and molecular insights into biological function and mechanism. Other reports that address fundamental questions in structural biology, such as structure-based examinations of protein evolution, folding, and/or design, will also be considered. We will consider the application of any method, experimental or computational, at high or low resolution, to conduct structural investigations, as long as the method is appropriate for the biological, functional, and mechanistic question(s) being addressed. Likewise, reports describing single-molecule analysis of biological mechanisms are welcome. In general, the editors encourage submission of experimental structural studies that are enriched by an analysis of structure-activity relationships and will not consider studies that solely report structural information unless the structure or analysis is of exceptional and broad interest. Studies reporting only homology models, de novo models, or molecular dynamics simulations are also discouraged unless the models are informed by or validated by novel experimental data; rationalization of a large body of existing experimental evidence and making testable predictions based on a model or simulation is often not considered sufficient.