snRNA核输出复合体的组装机制

IF 10.1 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2025-07-03 DOI:10.1038/s41594-025-01618-1

Yihu Xie, Yi Ren

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引用次数: 0

摘要

作为剪接体的关键部分，snrna的成熟涉及到新合成的snrna向细胞质的核输出。已知PHAX以磷酸化依赖的方式介导snRNA输出，但其潜在机制尚不清楚。含有phax的snRNA输出复合体的低温电镜结构现在提供了对该途径的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Assembly mechanism of the snRNA nuclear export complex

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Assembly mechanism of the snRNA nuclear export complex

Maturation of snRNAs, key parts of the spliceosome, involves nuclear export of newly synthesized snRNAs to the cytoplasm. PHAX is known to mediate snRNA export in a phosphorylation-dependent manner, but the underlying mechanism remains elusive. A cryo-EM structure of a PHAX-containing snRNA export complex now provides insights into the pathway.

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.