{"title":"snRNA核输出复合体的组装机制","authors":"Yihu Xie, Yi Ren","doi":"10.1038/s41594-025-01618-1","DOIUrl":null,"url":null,"abstract":"Maturation of snRNAs, key parts of the spliceosome, involves nuclear export of newly synthesized snRNAs to the cytoplasm. PHAX is known to mediate snRNA export in a phosphorylation-dependent manner, but the underlying mechanism remains elusive. A cryo-EM structure of a PHAX-containing snRNA export complex now provides insights into the pathway.","PeriodicalId":18822,"journal":{"name":"Nature structural & molecular biology","volume":"48 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Assembly mechanism of the snRNA nuclear export complex\",\"authors\":\"Yihu Xie, Yi Ren\",\"doi\":\"10.1038/s41594-025-01618-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Maturation of snRNAs, key parts of the spliceosome, involves nuclear export of newly synthesized snRNAs to the cytoplasm. PHAX is known to mediate snRNA export in a phosphorylation-dependent manner, but the underlying mechanism remains elusive. A cryo-EM structure of a PHAX-containing snRNA export complex now provides insights into the pathway.\",\"PeriodicalId\":18822,\"journal\":{\"name\":\"Nature structural & molecular biology\",\"volume\":\"48 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature structural & molecular biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/s41594-025-01618-1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature structural & molecular biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41594-025-01618-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Assembly mechanism of the snRNA nuclear export complex
Maturation of snRNAs, key parts of the spliceosome, involves nuclear export of newly synthesized snRNAs to the cytoplasm. PHAX is known to mediate snRNA export in a phosphorylation-dependent manner, but the underlying mechanism remains elusive. A cryo-EM structure of a PHAX-containing snRNA export complex now provides insights into the pathway.
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