点亮多肽：通过玫瑰孟加拉光催化从二硒酸酯中直接脱氢丙氨酸形成

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-07-01 DOI:10.1039/d5cc03361f

Mateusz Waliczek , Martyna Strączek , Piotr Stefanowicz

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引用次数: 0

摘要

提出了一种可见光驱动的方法，用于含有二硒肽的位点选择性转化为脱氢丙氨酸（Dha）。在水条件下，将孟加拉玫瑰作为光敏剂，该光催化过程通过氧化裂解Se-Se键，然后消除β，以获得高收率和化学选择性的Dha。这种温和的生物正交策略使下游肽功能化，并为合成后的肽编辑提供了一条实用的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Lighting up peptides: direct dehydroalanine formation from diselenides via Rose Bengal photocatalysis†

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Lighting up peptides: direct dehydroalanine formation from diselenides via Rose Bengal photocatalysis†

A visible-light-driven method for the site-selective conversion of diselenide-containing peptides to dehydroalanine (Dha) is presented. Using Rose Bengal as a photosensitizer in aqueous conditions, this photocatalytic process proceeds via oxidative cleavage of the Se–Se bond followed by β-elimination to afford Dha with high yield and chemoselectivity. This mild and bioorthogonal strategy enables downstream peptide functionalization and offers a practical route for post-synthetic peptide editing.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.