染色质的空间组织限制了ltr中备用启动子的激活

IF 29 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2025-07-03 DOI:10.1038/s41588-025-02238-7

引用次数: 0

摘要

转座因子（te）在基因组功能的进化中起着重要作用，但其在癌症发病中的确切作用机制尚不清楚。当NIPBL维持的拓扑相关结构域（TAD）层级丢失时，TE亚类长末端重复序列（lts）上的替代启动子被激活，可能导致癌基因的异常转录。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Spatial organization of chromatin restricts activation of poised alternative promoters in LTRs

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Spatial organization of chromatin restricts activation of poised alternative promoters in LTRs

Transposable elements (TEs) are important in the evolution of genomic functions but the mechanisms of their precise role in cancer pathogenesis is unclear. Alternative promoters at the TE subclass long terminal repeats (LTRs) are activated when topologically associating domain (TAD) hierarchy maintained by NIPBL is lost, potentially leading to aberrant transcription of oncogenes.

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution