垂体暗角:原发性黑素细胞瘤1例报告及文献复习。

IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Jiajing Ni, Jianhua Wang
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引用次数: 0

摘要

背景:原发性垂体黑色素细胞瘤是一种极为罕见的肿瘤,由于其黑色素浓度不均且可能出现出血事件,可能与垂体腺瘤合并中风相似。因此,对黑素细胞瘤的准确诊断至关重要。病例介绍:我们报告一例31岁的女性患者,她表现出一个月前开始的逐渐恶化的头痛。MRI显示蝶鞍明显增大,呈葫芦状病变,T1和T2信号短。与MRI结果相结合,CT扫描(非对比扫描和增强扫描)均显示鞍区有圆形致密区,增强扫描后增强增强。随后,该患者被安排进行经鼻内镜颅底肿瘤切除术和颅底重建。随后,组织病理学评估显示红色s -100(+)、红色黑色素A(+)、红色Ki-67(+5%)、红色黑色素瘤(+)、P53(+)、红色P53(+)和Ki-67(+),提示中度黑色素细胞瘤,在黑色素细胞肿瘤谱上定位于良性和恶性之间。结论:本病例报告评估了原发性黑色素细胞瘤的表现、主要影像学表现和组织病理学特征,这些特征有助于将原发性黑色素细胞瘤与其他肿瘤区分开来,并讨论了诊断后的关键管理和预后考虑因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Dark Corner of the Pituitary Gland: A Case Report and Literature Review of Primary Melanocytoma.

Background: Primary pituitary melanocytoma, an exceedingly rare tumor, may resemble pituitary adenoma with apoplexy owing to its heterogeneous melanin concentration and possible hemorrhagic events. An accurate diagnosis of melanocytoma is, therefore, essential.

Case presentation: We present a case of a 31-year-old female patient who exhibited a progressively worsening headache that commenced one month prior. MRI showed a significantly enlarged sella turcica with a gourd-shaped lesion that had a mixture of short T1 and T2 signals. In conjunction with the MRI findings, CT scans, both non-contrast and contrast-enhanced, revealed a circular, dense region in the sellar area, exhibiting heightened enhancement post-contrast administration. Subsequently, this patient was scheduled for endoscopic transnasal skull base tumor resection and skull base reconstruction. Later, histopathological assessment showed red-S-100 (+), red-melanin A (+), red-KI-67 (+5%), red-melanoma (+), P53 (+), red-P53 (+) and Ki-67 (+) and suggested an intermediate-grade melanocytoma, positioning this lesion between benign and malignant on the spectrum of melanocytic neoplasms.

Conclusion: This case report evaluated the presentation, key imaging findings, and histopathological features that help differentiate primary melanocytoma from other tumors and discussed key management and prognostic considerations following diagnosis.

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来源期刊
CiteScore
2.60
自引率
0.00%
发文量
246
审稿时长
1 months
期刊介绍: Current Medical Imaging Reviews publishes frontier review articles, original research articles, drug clinical trial studies and guest edited thematic issues on all the latest advances on medical imaging dedicated to clinical research. All relevant areas are covered by the journal, including advances in the diagnosis, instrumentation and therapeutic applications related to all modern medical imaging techniques. The journal is essential reading for all clinicians and researchers involved in medical imaging and diagnosis.
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