[基于心脏磁共振特征跟踪的高原扩张型心肌病的初步研究]。

Q3 Medicine

四川大学学报(医学版) Pub Date : 2025-03-20 DOI:10.12182/20250460201

Zhetao Wang, Chunhua Wang, Hongke Yin, Sisi Zhao, Jinghang Suo, Lei Wang, Yushu Chen, Peng Zhou, Fabao Gao

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引用次数: 0

摘要

目的：探讨心血管磁共振特征追踪（CMR-FT）在高原地区扩张型心肌病（DCM）患者心肌应变评估中的应用。方法：回顾性纳入29例生活在高海拔地区（DCM- h）的DCM患者、27例生活在低海拔平原环境（DCM- p）的DCM患者、23例生活在高海拔地区（HV-H）的健康志愿者和24例生活在低海拔平原环境（HV-P）的健康志愿者。所有受试者均采用3.0T快速稳态自由进动序列进行MRI扫描。利用后处理软件cvi42对采集到的CMR图像进行分析，得到左室功能和心肌应变参数。结果：与HV-H组比较，DCM-H组左心室舒张末期容积（LVEDV）和左心室收缩末期容积（LVESV）升高，左心室射血分数（LVEF）和卒中容积（LVSV）降低（P均< 0.01）。DCM-H组与DCM-P组心功能差异无统计学意义（P < 0.05）。DCM-H组整体径向应变（GRS）、整体周向应变（GCS）、整体纵向应变（GLS）的绝对值分别低于HV-P组（[14.5±6.5]%比[34.2±10.7]%、[-11.1±4.4]%比[-19.9±2.8]%、[-7.7±3.2]%比[-13.6±4.1]%），差异均有统计学意义（P均< 0.001）。DCM-H组的绝对GRS、GCS、GCS值均高于DCM-P组（分别为[14.5±6.5]%比[7.0±2.7]%、[-11.1±4.4]%比[-5.4±2.2]%、[-7.7±3.2]%比[-4.3±1.7]%，P均< 0.01）。结论：生活在高海拔地区的DCM患者心肌应变低于生活在高海拔地区的健康志愿者，但高于生活在低海拔平原环境的DCM患者。CMR-FT可定量评价高海拔地区DCM患者的心肌收缩力，具有较好的临床应用前景。

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[Preliminary Study of Dilated Cardiomyopathy at a High Altitude Based on Cardiac Magnetic Resonance Feature Tracking].

Objective: To investigate the application of cardiovascular magnetic resonance feature tracking (CMR-FT) in assessing myocardial strain in dilated cardiomyopathy (DCM) patients residing at high altitudes.

Methods: We retrospectively enrolled 29 DCM patients living at high altitudes (DCM-H), 27 DCM patients living in a low-altitude plain environment (DCM-P), 23 healthy volunteers living at a high altitude (HV-H), and 24 healthy volunteers living in a low-altitude plain environment (HV-P). All subjects underwent cine MRI scanning using a 3.0T rapid steady-state free precession sequence. The CMR images thus acquired were analyzed using cvi42, a post-processing software, to obtain left ventricular function and myocardial strain parameters.

Results: Compared with the HV-H group, the DCM-H group showed higher left ventricle end-diastolic volume (LVEDV) and left ventricle end-systolic volume (LVESV), and lower left ventricular ejection fraction (LVEF) and stroke volume ( LVSV) (all P < 0.01). No significant difference was observed in cardiac function between the DCM-H and DCM-P groups (all P > 0.05). The absolute values of global radial strain (GRS), global circumferential strain (GCS), and global longitudinal strain (GLS) in the DCM-H group were lower than those in the HV-P group ([14.5 ± 6.5]% vs. [34.2 ± 10.7]%, [－11.1 ± 4.4]% vs. [－19.9 ± 2.8]%, and [－7.7 ± 3.2]% vs. [－13.6 ± 4.1]%, respectively), with the differences being statistically significant (all P < 0.001). The DCM-H group had higher absolute GRS, GCS, and GCS values than the DCM-P group did ([14.5 ± 6.5]% vs. [7.0 ± 2.7]%, [－11.1 ± 4.4]% vs. [－5.4 ± 2.2]%, and [－7.7 ± 3.2]% vs. [－4.3 ± 1.7]%, respectivley, all P < 0.01).

Conclusion: Myocardial strain in DCM patients living at a high altitude is lower than that in healthy volunteers living at a high altitude, but higher than that in DCM patients living in a low-altitude plain environment. CMR-FT can be used to quantitatively assess myocardial contractility in DCM patients living at a high altitude, showing promise for clinical application.

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来源期刊

四川大学学报(医学版) Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

0.70

自引率

0.00%

发文量

8695

期刊介绍： "Journal of Sichuan University (Medical Edition)" is a comprehensive medical academic journal sponsored by Sichuan University, a higher education institution directly under the Ministry of Education of the People's Republic of China. It was founded in 1959 and was originally named "Journal of Sichuan Medical College". In 1986, it was renamed "Journal of West China University of Medical Sciences". In 2003, it was renamed "Journal of Sichuan University (Medical Edition)" (bimonthly). "Journal of Sichuan University (Medical Edition)" is a Chinese core journal and a Chinese authoritative academic journal (RCCSE). It is included in the retrieval systems such as China Science and Technology Papers and Citation Database (CSTPCD), China Science Citation Database (CSCD) (core version), Peking University Library's "Overview of Chinese Core Journals", the U.S. "Index Medica" (IM/Medline), the U.S. "PubMed Central" (PMC), the U.S. "Biological Abstracts" (BA), the U.S. "Chemical Abstracts" (CA), the U.S. EBSCO, the Netherlands "Abstracts and Citation Database" (Scopus), the Japan Science and Technology Agency Database (JST), the Russian "Abstract Magazine", the Chinese Biomedical Literature CD-ROM Database (CBMdisc), the Chinese Biomedical Periodical Literature Database (CMCC), the China Academic Journal Network Full-text Database (CNKI), the Chinese Academic Journal (CD-ROM Edition), and the Wanfang Data-Digital Journal Group.