ADCC对COVID-19疫苗反应的年龄相关缺陷

IF 6.9 1区医学 Q1 IMMUNOLOGY

NPJ Vaccines Pub Date : 2025-07-01 DOI:10.1038/s41541-025-01196-9

Benjamin L Sievers, Mazharul Altaf, Mark T K Cheng, Kimia Kamelian, Claire Cormie, Rainer Doffinger, Ravindra K Gupta

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引用次数: 0

摘要

我们调查了老年人（n = 50，平均年龄79）接种6剂SARS-CoV-2疫苗后的年龄相关效应。虽然中和滴度在各年龄组之间保持可比性，但fc介导的效应物功能随着年龄的增长而下降。通过替代ADCC信号分析，个体bbbb80显示出抗体依赖性细胞毒性（ADCC）降低，与IgG1结合减少相关。这些发现强调了fc介导的应答中与年龄相关的损伤，对老年人群的免疫保护和疫苗策略具有重要意义。

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Age-associated defect in ADCC response to COVID-19 vaccine.

We investigated age-associated effects of SARS-CoV-2 vaccination in elderly individuals (n = 50, mean age 79) after six SARS-CoV-2 vaccine doses. While neutralization titers remained comparable across age groups, Fc-mediated effector functions declined with age. Individuals >80 demonstrated reduced antibody-dependent cellular cytotoxicity (ADCC), via a surrogate ADCC-signaling assay, correlating with diminished IgG1 binding. These findings highlight age-related impairments in Fc-mediated responses, with implications for immune protection and vaccine strategies in older populations.

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来源期刊

NPJ Vaccines Immunology and Microbiology-Immunology

CiteScore

11.90

自引率

4.30%

发文量

146

审稿时长

11 weeks

期刊介绍： Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.