Athanasios Gkampenis, Eleni Romeo, Ioannis Koukoulithras, Marios Lampros, Spyridon Voulgaris, Andreas G Tzakos, George A Alexiou
{"title":"评价核医学技术在提高立体定向脑活检诊断准确性方面的有效性的系统综述。","authors":"Athanasios Gkampenis, Eleni Romeo, Ioannis Koukoulithras, Marios Lampros, Spyridon Voulgaris, Andreas G Tzakos, George A Alexiou","doi":"10.1007/s10143-025-03698-5","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>The aim of the present systematic review is to assess the effectiveness of nuclear medicine methods to improve the diagnostic accuracy of stereotactic brain biopsies (SBB).</p><p><strong>Methods: </strong>A search in Medline, Cochrane, and Scopus databases until 22<sup>nd</sup> August 2024 was performed to retrieve relevant studies, aided by a manual search in Google Scholar. After applying predetermined inclusion and exclusion criteria, a data extraction was performed. The risk of bias and concerns regarding applicability were evaluated using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool.</p><p><strong>Results: </strong>Thirteen studies (9 prospective and 4 retrospective) with a total of 337 patients were included in this systematic review. There was a high risk of bias at least in one domain in all studies, while in 4 studies there were high concerns regarding applicability at least in one domain. Positron emission tomography (PET) was used in 12 studies and single photon emission computed tomography (SPECT) in 1 study to design the trajectories of the biopsies. A diagnosis was established through SBB in 282 out of 291 patients, while for the remaining 46 patients there was no relevant data in the studies. Two studies provided data on sensitivity (76 - 81.2 %), specificity (50 - 80 %), and Area Under the Curve (AUC) (56.2 - 89 %).</p><p><strong>Conclusion: </strong>Nuclear medicine has the potential to increase the diagnostic accuracy of SBB by improving targeting precision. Among the radiotracers, <sup>11</sup>C-methionine emerged as the most effective, providing superior visualization of the metabolic active region of a brain tumor.</p>","PeriodicalId":19184,"journal":{"name":"Neurosurgical Review","volume":"48 1","pages":"538"},"PeriodicalIF":2.5000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A systematic review evaluating the effectiveness of nuclear medicine techniques in enhancing the diagnostic accuracy of stereotactic brain biopsies.\",\"authors\":\"Athanasios Gkampenis, Eleni Romeo, Ioannis Koukoulithras, Marios Lampros, Spyridon Voulgaris, Andreas G Tzakos, George A Alexiou\",\"doi\":\"10.1007/s10143-025-03698-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>The aim of the present systematic review is to assess the effectiveness of nuclear medicine methods to improve the diagnostic accuracy of stereotactic brain biopsies (SBB).</p><p><strong>Methods: </strong>A search in Medline, Cochrane, and Scopus databases until 22<sup>nd</sup> August 2024 was performed to retrieve relevant studies, aided by a manual search in Google Scholar. After applying predetermined inclusion and exclusion criteria, a data extraction was performed. The risk of bias and concerns regarding applicability were evaluated using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool.</p><p><strong>Results: </strong>Thirteen studies (9 prospective and 4 retrospective) with a total of 337 patients were included in this systematic review. There was a high risk of bias at least in one domain in all studies, while in 4 studies there were high concerns regarding applicability at least in one domain. Positron emission tomography (PET) was used in 12 studies and single photon emission computed tomography (SPECT) in 1 study to design the trajectories of the biopsies. A diagnosis was established through SBB in 282 out of 291 patients, while for the remaining 46 patients there was no relevant data in the studies. Two studies provided data on sensitivity (76 - 81.2 %), specificity (50 - 80 %), and Area Under the Curve (AUC) (56.2 - 89 %).</p><p><strong>Conclusion: </strong>Nuclear medicine has the potential to increase the diagnostic accuracy of SBB by improving targeting precision. Among the radiotracers, <sup>11</sup>C-methionine emerged as the most effective, providing superior visualization of the metabolic active region of a brain tumor.</p>\",\"PeriodicalId\":19184,\"journal\":{\"name\":\"Neurosurgical Review\",\"volume\":\"48 1\",\"pages\":\"538\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurosurgical Review\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10143-025-03698-5\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurosurgical Review","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10143-025-03698-5","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
A systematic review evaluating the effectiveness of nuclear medicine techniques in enhancing the diagnostic accuracy of stereotactic brain biopsies.
Purpose: The aim of the present systematic review is to assess the effectiveness of nuclear medicine methods to improve the diagnostic accuracy of stereotactic brain biopsies (SBB).
Methods: A search in Medline, Cochrane, and Scopus databases until 22nd August 2024 was performed to retrieve relevant studies, aided by a manual search in Google Scholar. After applying predetermined inclusion and exclusion criteria, a data extraction was performed. The risk of bias and concerns regarding applicability were evaluated using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool.
Results: Thirteen studies (9 prospective and 4 retrospective) with a total of 337 patients were included in this systematic review. There was a high risk of bias at least in one domain in all studies, while in 4 studies there were high concerns regarding applicability at least in one domain. Positron emission tomography (PET) was used in 12 studies and single photon emission computed tomography (SPECT) in 1 study to design the trajectories of the biopsies. A diagnosis was established through SBB in 282 out of 291 patients, while for the remaining 46 patients there was no relevant data in the studies. Two studies provided data on sensitivity (76 - 81.2 %), specificity (50 - 80 %), and Area Under the Curve (AUC) (56.2 - 89 %).
Conclusion: Nuclear medicine has the potential to increase the diagnostic accuracy of SBB by improving targeting precision. Among the radiotracers, 11C-methionine emerged as the most effective, providing superior visualization of the metabolic active region of a brain tumor.
期刊介绍：
The goal of Neurosurgical Review is to provide a forum for comprehensive reviews on current issues in neurosurgery. Each issue contains up to three reviews, reflecting all important aspects of one topic (a disease or a surgical approach). Comments by a panel of experts within the same issue complete the topic. By providing comprehensive coverage of one topic per issue, Neurosurgical Review combines the topicality of professional journals with the indepth treatment of a monograph. Original papers of high quality are also welcome.
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