白癜风的免疫发病机制及间充质基质/干细胞在白癜风治疗中的潜在作用。

IF 6.1 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Rui-Lin Yang, De-Zhi Zhao, Yi-Bing Yang, Han-Xiao Wei, Kang Yang, Yu-Jie Zhao, Wei-Hong Wan, Zu-Lin Liu, Yuan Feng, Qian Zhang, Tao Zhang
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引用次数: 0

摘要

白癜风是一种影响全球数百万人的皮肤病,通常由黑色素细胞损伤或功能障碍引起。尽管有各种治疗选择,白癜风的管理仍然是一个重大挑战,强调了创新治疗方法的必要性。目前,间充质基质细胞(Mesenchymal Stromal Cells, MSCs)由于其显著的旁分泌作用,在许多疾病的研究中作为一种治疗方式获得了突出的地位,使其成为免疫调节和组织修复的一种有前途的策略。MSCs对特定细胞因子的下调有可能增强白癜风病变的微环境,从而有助于治疗结果。本文旨在综述白癜风的免疫发病机制,某些细胞因子在其发病机制中的作用,以及间充质干细胞在白癜风治疗中的治疗潜力。本综述将为今后MSCs在白癜风治疗中的应用提供参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The immunological pathogenesis of vitiligo and the potential role of mesenchymal stromal/stem cells in its treatment.

Vitiligo is a dermatological condition that affects millions of individuals globally and is frequently precipitated by damage to or dysfunction of melanocytes. Despite the availability of various therapeutic options, the management of vitiligo remains a significant challenge, underscoring the necessity for innovative treatment approaches. Currently, Mesenchymal Stromal Cells (MSCs) have gained prominence as a therapeutic modality in the research of numerous diseases, owing to their remarkable paracrine effects, making them a promising strategy for immunomodulation and tissue repair. The downregulation of specific cytokines by MSCs has the potential to enhance the microenvironment of vitiligo lesions, thereby contributing to therapeutic outcomes. This article aims to review the immunologic pathogenesis of vitiligo, the involvement of certain cytokines in its pathogenesis, and the therapeutic potential of MSCs in the treatment of vitiligo. It is anticipated that this review will serve as a reference for future therapeutic strategies involving MSCs in the management of vitiligo.

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来源期刊
Journal of Translational Medicine
Journal of Translational Medicine 医学-医学:研究与实验
CiteScore
10.00
自引率
1.40%
发文量
537
审稿时长
1 months
期刊介绍: The Journal of Translational Medicine is an open-access journal that publishes articles focusing on information derived from human experimentation to enhance communication between basic and clinical science. It covers all areas of translational medicine.
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