成软骨细胞瘤患者的复发与手术佐剂的使用无关:一项单中心回顾性研究

IF 2 3区 医学 Q3 ONCOLOGY
Brandon S Gettleman, Abigail N Padilla, Adrian Lin, Kian Jeshion-Nelson, Tishya A L Wren, Bruce R Pawel, Vernon T Tolo, Alexander B Christ
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引用次数: 0

摘要

背景和目的:成软骨细胞瘤是一种罕见的良性骨肿瘤,影响年轻患者的长骨骨骺。本研究描述了我们队列中的复发发生率及其与佐剂的关系。次要目标包括确定复发和角畸形发展的危险因素。方法:对2004年至2021年接受成软骨细胞瘤手术治疗的儿科患者进行回顾性分析。符合条件的患者至少有6个月的随访,初始肿瘤无复发,并有完整的图表数据。回顾了人口统计学、肿瘤位置、治疗细节、复发和术后并发症的医疗记录。结果:39例患者符合纳入标准(平均年龄13.7±2.5岁,平均随访27.1±12.9个月)。肿瘤最常见于股骨(43.6%,17/39)。4例复发(10.3%,4/39)。机械佐剂(p = 0.464)、化学佐剂(p = 0.387)和热佐剂(p = 0.078)与复发无显著相关性。与女性性别(p = 0.058)、年龄(p = 0.703)、肿瘤大小(p = 0.425)也无显著相关性。2例患者出现角畸形(5.1%,2/39)。位置不影响角畸形发育或生长障碍。结论:我们发现在成软骨细胞瘤治疗中,辅助类型和复发之间没有明显的联系。两例角度畸形均发生在胫骨病变处(16.7%,2/12)。医生应考虑到这些发现的患者随访和家庭咨询的长期结果后,软骨细胞瘤治疗。证据等级:三级。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recurrence in Patients With Chondroblastoma Is Not Associated With Use of Surgical Adjuvants: A Single Center Retrospective Review.

Background and objectives: Chondroblastoma is a rare, benign bone tumor that affects the epiphyses of long bones in young patients. This study describes the incidence of recurrence in our cohort and its association with adjuvants. Secondary objectives include identifying risk factors for recurrence and the development of angular deformity.

Methods: A retrospective review from 2004 to 2021 examined pediatric patients surgically treated for chondroblastoma. Eligible patients had at least 6 months of follow-up, initial non-recurrent tumors, and complete chart data. Medical records were reviewed for demographics, tumor location, treatment details, recurrence, and postoperative complications.

Results: Thirty-nine patients met inclusion criteria (mean age 13.7 ± 2.5 years, mean follow-up 27.1 ± 12.9 months). Tumors were most common in the femur (43.6%, 17/39). Four individuals experienced recurrence (10.3%, 4/39). There was no significant association between recurrence and mechanical adjuvants (p = 0.464), chemical adjuvants (p = 0.387), and thermal adjuvants (p = 0.078). There was also no significant association with female sex (p = 0.058), age (p = 0.703), or tumor size (p = 0.425). Two patients developed angular deformity (5.1%, 2/39). Location did not affect angular deformity development or growth disturbance.

Conclusions: We found no significant link between adjuvant type and recurrence in chondroblastoma treatment. Both angular deformity cases occurred in tibial lesions (16.7%, 2/12). Physicians should consider these findings for patient follow-up and family counseling on long-term outcomes after chondroblastoma treatment.

Level of evidence: Level III.

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来源期刊
CiteScore
4.70
自引率
4.00%
发文量
367
审稿时长
2 months
期刊介绍: The Journal of Surgical Oncology offers peer-reviewed, original papers in the field of surgical oncology and broadly related surgical sciences, including reports on experimental and laboratory studies. As an international journal, the editors encourage participation from leading surgeons around the world. The JSO is the representative journal for the World Federation of Surgical Oncology Societies. Publishing 16 issues in 2 volumes each year, the journal accepts Research Articles, in-depth Reviews of timely interest, Letters to the Editor, and invited Editorials. Guest Editors from the JSO Editorial Board oversee multiple special Seminars issues each year. These Seminars include multifaceted Reviews on a particular topic or current issue in surgical oncology, which are invited from experts in the field.
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