A Self-Generated Electricity-Driven Sclera reinforcement bionic piezoelectric patch for Management of High Myopia.

Background: High myopia (HM) is a progressive ocular condition characterized by excessive axial elongation and severe refractive errors, often leading to sight-threatening complications. The underlying pathological driver of HM is the weakening of scleral biomechanics, making the sclera a key therapeutic target. While posterior scleral reinforcement (PSR) has been established as an effective intervention to strengthen the sclera, currently available PSR materials often fail to fully meet clinical demands.

Results: Inspired by the electric eel, which generates surface electrolytes to facilitate electric discharge and influence interactions with its surroundings, we developed a biomimetic piezoelectric patch (BPP@PVDF) for HM treatment. This patch integrates a bovine pericardium (BPP) scaffold with a piezoelectric polyvinylidene fluoride (PVDF) film, endowing the BPP with electrical properties and improved cell adhesion. Through electrical activation, the BPP enhances scleral mechanical strength and promotes collagen synthesis, effectively mitigating axial elongation in myopia.

Conclusions: Both in vitro and in vivo experiments demonstrate that our precisely designed patch provided a stable and effective solution for reducing progressive axial elongation in HM. By leveraging nanotechnology, electrical stimulation, and scleral reinforcement surgery, this study offers a groundbreaking approach with significant implications for both scientific research and clinical practice. Our strategy paves the way for enhanced surgical outcomes in HM treatment, offering a promising avenue for future therapeutic advancements.