后抗生素时代对抗抗菌素耐药性的新治疗策略。

IF 3.5 4区 生物学 Q2 MICROBIOLOGY
Roghayeh Mohammadzadeh, Shahla Shahbazi, Niloufar Khodaei, Samira Sabzi
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引用次数: 0

摘要

抗菌素耐药性(AMR)是一个严重的全球卫生问题。这篇综述旨在探讨抗AMR的替代治疗策略。目标是评估通过新机制靶向耐药病原体的新兴治疗方法,绕过传统抗生素的局限性。最近的研究强调了几种有前途的替代方案,包括抗体、抗菌肽、细菌素、噬菌体和益生菌(在临床试验中)和合成抗菌肽、抗毒策略、转基因噬菌体、抗菌寡核苷酸、CRISPR-Cas9和掠食性细菌(在研究阶段)。这些疗法通过靶向特定的细菌机制、降低毒性和避免耐药性,证明了克服AMR的潜力。抗微生物药物耐药性的替代疗法带来了巨大的希望,为治疗提供了新的途径。尽管在优化和递送方面存在挑战,但这些疗法可能会彻底改变细菌感染的治疗方式。持续的研究对于解决障碍并确保这些疗法能够在临床环境中安全有效地实施,塑造感染管理的未来至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Emerging Therapeutic Strategies to Combat Antimicrobial Resistance in the Post-Antibiotic Era.

Antimicrobial resistance (AMR) is a serious global health issue. This review aims to explore alternative therapeutic strategies for combating AMR. The goal is to evaluate emerging treatments that target resistant pathogens through novel mechanisms, bypassing the limitations of traditional antibiotics. Recent researches highlight several promising alternatives, including antibodies, antimicrobial peptides, bacteriocins, bacteriophages, and probiotics (in the clinical trials) and synthetic antimicrobial peptides, anti-virulence strategies, genetically modified phages, antibacterial oligonucleotides, CRISPR-Cas9, and predatory bacteria (in the research stage). These therapies demonstrate potential to overcome AMR by targeting specific bacterial mechanisms, reducing toxicity, and evading resistance. Alternative therapies for AMR present significant promise, offering new avenues for treatment. Despite challenges in optimization and delivery, these therapies could revolutionize the way bacterial infections are treated. Continued research is crucial to address hurdles and ensure these therapies can be safely and effectively implemented in clinical settings, shaping the future of infection management.

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来源期刊
Journal of Basic Microbiology
Journal of Basic Microbiology 生物-微生物学
CiteScore
6.10
自引率
0.00%
发文量
134
审稿时长
1.8 months
期刊介绍: The Journal of Basic Microbiology (JBM) publishes primary research papers on both procaryotic and eucaryotic microorganisms, including bacteria, archaea, fungi, algae, protozoans, phages, viruses, viroids and prions. Papers published deal with: microbial interactions (pathogenic, mutualistic, environmental), ecology, physiology, genetics and cell biology/development, new methodologies, i.e., new imaging technologies (e.g. video-fluorescence microscopy, modern TEM applications) novel molecular biology methods (e.g. PCR-based gene targeting or cassettes for cloning of GFP constructs).
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