DDOST在相关疾病中的失调研究进展。

IF 3.1 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Glycoconjugate Journal Pub Date : 2025-07-02 DOI:10.1007/s10719-025-10188-9

Haoan Sun, Chunbao Xie

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引用次数: 0

摘要

DDOST是n -糖基化低聚糖转移酶的重要亚基，与蛋白质n -糖基化密切相关。有研究报道DDOST的异常表达与先天性糖基化障碍、实体瘤等疾病有关。为了更好地了解DDOST在疾病中的研究进展，本文就DDOST的基本功能、相互作用分子、ddot -先天性糖基化障碍（ddot - cdg）和实体肿瘤进行了综述。本文的研究结果将为研究人员更好地了解DDOST的功能和研究其具体作用机制奠定基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Progress in research on DDOST dysregulation in related diseases.

DDOST is an important subunit of N-glycosylated oligosaccharyltransferase and is closely related to protein N-glycosylation. Some studies have reported that abnormal expression of DDOST is associated with congenital disorders of glycosylation, solid tumours and other diseases. To better understand the progress of research on DDOST in diseases, we herein provide a comprehensive review of the basic functions of DDOST, interactions molecules, DDOST-congenital disorders of glycosylation (DDOST-CDG) and solid tumours. Our review findings will lay a foundation for researchers to better understand the functions of DDOST and to investigate its specific mechanisms of action.

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来源期刊

Glycoconjugate Journal 生物-生化与分子生物学

CiteScore

6.00

自引率

3.30%

发文量

审稿时长

1 months

期刊介绍： Glycoconjugate Journal publishes articles and reviews on all areas concerned with: function, composition, structure, biosynthesis, degradation, interactions, recognition and chemo-enzymatic synthesis of glycoconjugates (glycoproteins, glycolipids, oligosaccharides, polysaccharides and proteoglycans), biochemistry, molecular biology, biotechnology, immunology and cell biology of glycoconjugates, aspects related to disease processes (immunological, inflammatory, arthritic infections, metabolic disorders, malignancy, neurological disorders), structural and functional glycomics, glycoimmunology, glycovaccines, organic synthesis of glycoconjugates and the development of methodologies if biologically relevant, glycosylation changes in disease if focused on either the discovery of a novel disease marker or the improved understanding of some basic pathological mechanism, articles on the effects of toxicological agents (alcohol, tobacco, narcotics, environmental agents) on glycosylation, and the use of glycotherapeutics. Glycoconjugate Journal is the official journal of the International Glycoconjugate Organization, which is responsible for organizing the biennial International Symposia on Glycoconjugates.