鼻内给药:配方因素和对用户体验的见解。

IF 3.4 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Shabbir Lobo, Zhangjie Xi, Debanjan Das, Norell M Hadzimichalis, John A Creek
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引用次数: 0

摘要

改善鼻喷雾剂的使用体验通常不被视为关键的产品要求,即使鼻内使用后的苦味,酸味,涩味或灼烧感可能导致严重的排斥,消费者不遵守推荐的使用方法和产品拒绝。学术界和工业界都对喷雾剂的配方特征和消费者偏好进行了广泛的研究,以使患者更“接受”鼻腔喷雾剂。由于缺乏对这些工作的整理摘要,这篇综述文章试图收集和总结这些研究,解决影响喷雾后体验的各种属性,并为最大限度地提高用户依从性提供建议。我们系统地分类了一系列可能导致使用鼻喷雾剂不愉快体验的因素,包括鼻子的解剖特征、配方和设备特性、配方成分和剂量等。此外,我们整理了来自制药和非制药领域的相关信息,以创建一个全面的知识库来框架问题的范围。不愉快的感官属性可以通过设计配方来控制,并彻底了解产品-设备相互作用和赋形剂的新用途。通过选择辅料,如味道掩蔽剂、香料和新型聚合物,可以调节产品在鼻道中的行为,以阻止喷雾剂使用时的灼烧、涩味或苦味。本文全面详细地讨论了这些因素,同时提供了解决方案,以确保卓越的产品体验。本文还讨论了一些新技术和辅料的采用和依从性策略所面临的挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Intranasal Delivery: Formulation Factors and Insights Into User Experience.

Improving nasal spray use experience is typically not addressed as a key product requirement even though sensations of bitterness, sourness, astringency, or burning after intranasal application can cause significant repulsion, consumer non-compliance from recommended usage and product rejection. Extensive studies have been carried out by academia and industry alike into the formulation characteristics of sprays and consumer preferences to make nasal sprays more "acceptable" by patients. Due to lack of a collative synopsis of these works, this review article attempts to gather and summarize these studies, address the various attributes that impact post spray experience, and provide suggestions towards maximizing user compliance. We systematically categorized a range of factors which can contribute to unpleasant experiences using nasal sprays including anatomical characteristics of the nose, formulation and device properties, formulation components and dosages, etc. Furthermore, we collated relevant information from pharmaceutical and non-pharmaceutical domains to create a comprehensive knowledge base to frame the scope of the issue. Unpleasant sensorial attributes can be controlled by designing the formulation with a thorough understanding of product-device interactions and novel use of excipients. By choosing excipients such as taste masking agents, flavors, and novel polymers the behavior of the product in the nasal canal can be modulated to block the burning, astringent or bitterness sensation on spray use. This paper discusses these factors in comprehensive detail while offering solutions to ensure a superior product experience. The paper also discusses challenges to adoption and compliance strategies of some newer techniques and excipients.

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来源期刊
AAPS PharmSciTech
AAPS PharmSciTech 医学-药学
CiteScore
6.80
自引率
3.00%
发文量
264
审稿时长
2.4 months
期刊介绍: AAPS PharmSciTech is a peer-reviewed, online-only journal committed to serving those pharmaceutical scientists and engineers interested in the research, development, and evaluation of pharmaceutical dosage forms and delivery systems, including drugs derived from biotechnology and the manufacturing science pertaining to the commercialization of such dosage forms. Because of its electronic nature, AAPS PharmSciTech aspires to utilize evolving electronic technology to enable faster and diverse mechanisms of information delivery to its readership. Submission of uninvited expert reviews and research articles are welcomed.
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