自推进原位聚合纳米颗粒激活STING通路增强膀胱癌免疫治疗（Adv. Sci. 25/2025）

IF 14.1 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2025-07-03 DOI:10.1002/advs.202570190

Lei Peng, Anguo Zhao, Rongkang Li, Yujun Liu, Daitian Tang, Dashi Deng, Qi Zhuang, Rui Liang, Shaohua Zhang, Song Wu

{"title":"自推进原位聚合纳米颗粒激活STING通路增强膀胱癌免疫治疗（Adv. Sci. 25/2025）","authors":"Lei Peng, Anguo Zhao, Rongkang Li, Yujun Liu, Daitian Tang, Dashi Deng, Qi Zhuang, Rui Liang, Shaohua Zhang, Song Wu","doi":"10.1002/advs.202570190","DOIUrl":null,"url":null,"abstract":"Enhanced Bladder Cancer ImmunotherapyA self-propelled nanomedicine delivery system forms Mn-cGAMP@PDA-urease (DMCU) nanoparticles in the bladder via in situ polymerization of dopamine hydrochloride, Mn2+, cGAMP, and urease. The urease-driven propulsion enhances retention and drug delivery. These nanoparticles activate the STING pathway, stimulating dendritic cells and T cells to boost anti-bladder cancer immunity. More details can be found in article number 2502750 by Rui Liang, Shaohua Zhang, Song Wu, and co-workers.\n\n <figure>\n <div><picture>\n <source></source></picture>\n </div>\n </figure>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 25","pages":""},"PeriodicalIF":14.1000,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570190","citationCount":"0","resultStr":"{\"title\":\"Self-Propelled In Situ Polymerized Nanoparticles Activating the STING Pathway for Enhanced Bladder Cancer Immunotherapy (Adv. Sci. 25/2025)\",\"authors\":\"Lei Peng, Anguo Zhao, Rongkang Li, Yujun Liu, Daitian Tang, Dashi Deng, Qi Zhuang, Rui Liang, Shaohua Zhang, Song Wu\",\"doi\":\"10.1002/advs.202570190\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Enhanced Bladder Cancer ImmunotherapyA self-propelled nanomedicine delivery system forms Mn-cGAMP@PDA-urease (DMCU) nanoparticles in the bladder via in situ polymerization of dopamine hydrochloride, Mn2+, cGAMP, and urease. The urease-driven propulsion enhances retention and drug delivery. These nanoparticles activate the STING pathway, stimulating dendritic cells and T cells to boost anti-bladder cancer immunity. More details can be found in article number 2502750 by Rui Liang, Shaohua Zhang, Song Wu, and co-workers.\\n\\n <figure>\\n <div><picture>\\n <source></source></picture>\\n </div>\\n </figure>\",\"PeriodicalId\":117,\"journal\":{\"name\":\"Advanced Science\",\"volume\":\"12 25\",\"pages\":\"\"},\"PeriodicalIF\":14.1000,\"publicationDate\":\"2025-07-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570190\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Science\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/advs.202570190\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Science","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/advs.202570190","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

一种自行式纳米药物递送系统通过盐酸多巴胺、Mn2+、cGAMP和脲酶的原位聚合在膀胱中形成Mn-cGAMP@PDA-urease （DMCU）纳米颗粒。脲驱动的推进增强了药物的保留和输送。这些纳米颗粒激活STING通路，刺激树突状细胞和T细胞，增强抗膀胱癌的免疫力。更多的细节可以在梁睿，张少华，吴松和同事的文章编号2502750中找到。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Self-Propelled In Situ Polymerized Nanoparticles Activating the STING Pathway for Enhanced Bladder Cancer Immunotherapy (Adv. Sci. 25/2025)

查看原文本刊更多论文

Self-Propelled In Situ Polymerized Nanoparticles Activating the STING Pathway for Enhanced Bladder Cancer Immunotherapy (Adv. Sci. 25/2025)

Enhanced Bladder Cancer Immunotherapy

A self-propelled nanomedicine delivery system forms Mn-cGAMP@PDA-urease (DMCU) nanoparticles in the bladder via in situ polymerization of dopamine hydrochloride, Mn²⁺, cGAMP, and urease. The urease-driven propulsion enhances retention and drug delivery. These nanoparticles activate the STING pathway, stimulating dendritic cells and T cells to boost anti-bladder cancer immunity. More details can be found in article number 2502750 by Rui Liang, Shaohua Zhang, Song Wu, and co-workers.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.