揭示NGLY1在细胞稳态和相关疾病中的作用

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Cellular signalling Pub Date : 2025-06-30 DOI:10.1016/j.cellsig.2025.111971

Chenxi Zhan , Xuye Zhao , Yaoxin Wei , Renqiang Yang , Nianlong Yan

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引用次数: 0

摘要

NGLY1是一种细胞质酶，在内质网相关降解（ERAD）过程中从错误折叠的糖蛋白中去除n -聚糖，这是一种关键的蛋白质质量控制机制。ERAD与泛素-蛋白酶体系统（UPS）协调，协同工作以维持细胞蛋白质稳态和减轻蛋白质毒性。新出现的证据强调了NGLY1在蛋白质平衡活性、自噬、内质网应激和相关领域的多方面作用，所有这些都与许多疾病有关，包括神经退行性疾病和癌症等。为了充分认识NGLY1在细胞内稳态中的作用，本文就NGLY1在细胞内稳态及相关疾病中的相关分子机制及其治疗方法等方面的研究进展进行综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Unveiling roles of NGLY1 in cellular homeostasis and related diseases

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Unveiling roles of NGLY1 in cellular homeostasis and related diseases

NGLY1, a cytoplasmic enzyme, removes N-glycans from misfolded glycoproteins during endoplasmic reticulum-associated degradation (ERAD), a critical protein quality control mechanism. ERAD coordinates with the ubiquitin-proteasome system (UPS), working synergistically to maintain cellular proteostasis and mitigate protein toxicity. Emerging evidence highlights the multifaceted roles of NGLY1 in proteostasis activity, autophagy, endoplasmic reticulum stress, and related areas, all of which are connected to numerous diseases, including neurodegenerative disorders and cancer, among others. To fully understand the function of NGLY1 in cellular homeostasis, this review comprehensively discusses recent research progress and the related molecular mechanisms of NGLY1 in cellular homeostasis and associated diseases, as well as the therapeutic approaches.

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来源期刊

Cellular signalling 生物-细胞生物学

CiteScore

8.40

自引率

0.00%

发文量

250

审稿时长

27 days

期刊介绍： Cellular Signalling publishes original research describing fundamental and clinical findings on the mechanisms, actions and structural components of cellular signalling systems in vitro and in vivo. Cellular Signalling aims at full length research papers defining signalling systems ranging from microorganisms to cells, tissues and higher organisms.