t细胞淋巴瘤的诊断和治疗在科索沃，横断面研究

IF 1.6 Q3 HEMATOLOGY

Hematology, Transfusion and Cell Therapy Pub Date : 2025-07-01 DOI:10.1016/j.htct.2025.103930

Adriatik Berisha

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引用次数: 0

摘要

背景：与其他淋巴细胞恶性肿瘤相比，t细胞淋巴瘤是科索沃较为常见的血液恶性肿瘤。在其他亚型中，间变性大t细胞淋巴瘤是最常见的。这种疾病的诊断在过去几年中有所增加，但化疗和其他支持性护理的治疗仍然面临许多挑战。在这项研究中，我们旨在更好地定义这些疾病在科索沃的表现特征。方法横断面回顾性流行病学研究。数据收集于2018年6月至2023年6月期间。数据来自科索沃UCC血液学诊所的化疗治疗方案书。研究人群为年龄在18岁及以上，在科索沃血液学诊所诊断并治疗过t细胞淋巴瘤的患者，不分性别。诊断是基于组织病理学和免疫组织化学分析的淋巴结或骨髓活检。结果本组共确诊治疗t细胞淋巴瘤44例，以间变性大t细胞淋巴瘤（n = 9,19.5%）最为常见，其次为肠病相关t细胞淋巴瘤（n = 7,14.6%）和NK/ t细胞淋巴瘤（n = 5,9.7%）。其他病例包括T淋巴瘤/白血病伴肝硬化肝炎和唯一的γ / δ T细胞淋巴瘤病例。44例TCL患者中，29例采用CHOP方案作为一线化疗方案。结论stcl在科索沃较为常见，5年内确诊44例。大多数患者采用CHOP化疗方案作为一线治疗。治疗的结果是成功地在少数患者中实现了缓解。未达到缓解的患者接受了第二种治疗方案，结果好坏参半，并被送往移植中心。延长生存是例外，证实需要新的靶向方法。

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T-CELL LYMPHOMA DIAGNOSIS AND TREATMENT IN KOSOVO, A CROSS SECTIONAL STUDY

Background

T-cell Lymphoma is a relatively common hematological malignancy in Kosovo compared to the other lymphoid malignancies. Among the other subtypes, Anaplastic large T-cell lymphoma is the most common. The diagnosis of this disease has increased in the last few years and the treatment with chemotherapy and other supportive care has still many challenges. In this study we aimed to better define the presenting features of these diseases in Kosovo.

Methods

Cross sectional retrospective epidemiological study. The data was collected during the period of June 2018 to June 2023.The data were collected from the chemotherapy treatment protocol books in the Hematology clinic of the UCC Kosovo. The studied population was constituted by patients aged 18-years old and older, both genders, diagnosed the treated with T-cell Lymphoma in the Hematology clinic of Kosovo. The diagnosis was made based on histopathological and immunohistochemical analysis of lymph nodes or bone marrow biopsies.

Results

During the period considered time-period, 44 patients were diagnosed and treated with T-cell lymphoma, the most common was Anaplastic large T-cell lymphoma (n = 9, 19.5%) followed by Enteropathy associated T-cell lymphomawith (n = 7, 14.6%), and NK/T-cell lymphoma with (n = 5, 9.7%). Other cases included a T Lymphoma/Leukemia accompanied by cirrhosis hepatis and the only case of gamma/delta T-cell lymphoma. Among the 44 TCL, 29 were treated with CHOP regimen as first line chemotherapy.

Conclusions

TCL are relatively common in Kosovo, with 44 cases diagnosed over 5-years. The majority of patients were treated with the CHOP chemotherapy protocol as first line therapy. The results of the treatments were successful in achieving remissions in a small number of patients. The patients that did not achieve remission received a second treatment protocol with mixed results and were sent to transplant center. Prolonged survival was exceptional, confirming the need for new targeted approaches.

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