急性淋巴细胞白血病患儿体位控制的研究

IF 1.6 Q3 HEMATOLOGY

Hematology, Transfusion and Cell Therapy Pub Date : 2025-07-01 DOI:10.1016/j.htct.2025.103884

Fulya Ipek-Erdem , Sena Sonkaya , Arzu Genç , Şebnem Yılmaz

{"title":"急性淋巴细胞白血病患儿体位控制的研究","authors":"Fulya Ipek-Erdem , Sena Sonkaya , Arzu Genç , Şebnem Yılmaz","doi":"10.1016/j.htct.2025.103884","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>Children with leukemia may face balance impairments due to somatosensory, motor, muscular, and cognitive deficits that can persist into adulthood and increase fall risk. This study aimed to evaluate postural control in children with Acute Lymphoblastic Leukemia (ALL) undergoing consolidation therapy by comparing their performance with normative data to identify potential treatment-related impairments in sensory integration and balance.</div></div><div><h3>Methodology</h3><div>Thirteen children with ALL were recruited at Dokuz Eylül University, Faculty of Physiotherapy and Rehabilitation in Turkey, and divided into two age groups: 6–7 years (n = 9) and 8–9 years (n = 4). Static balance was evaluated using the modified Clinical Test for Sensory Interaction on Balance (mCTSIB) with the Balance Master system. The test assessed postural control under four conditions: Eyes Open-firm surface (FirmEO), Eyes Closed-firm surface (FirmEC), eyes open-unstable (foam) surface (FoamEO), and eyes closed-unstable (foam) surface (FoamEC). The center of gravity's average sway speed (°/s) was measured for each condition, with higher values indicating reduced balance capability. Normative data for each condition were obtained from previous studies on healthy children.</div></div><div><h3>Results</h3><div>In the 6–7 years group, sway speeds during FirmEO and FirmEC were 0.92 s and 0.97 s, respectively, compared to norms of 0.70s and 0.92s. Under foam conditions, FoamEO reached 1.31s (norm: 1.20s), while FoamEC was 1.81s, nearly identical to the normative 1.80s. In the 8–9 years group, FirmEO was 0.55s (norm: 0.40s) and FirmEC was 0.65s (norm: 0.53s). FoamEO measured 0.82s (norm: 0.89s), whereas FoamEC was 1.70s (norm: 1.47s). Overall, these results suggest that children with ALL generally exhibit elevated sway speeds ‒ particularly under firm conditions ‒ implying impaired postural control and potential challenges in sensory integration.</div></div><div><h3>Conclusion</h3><div>Our findings demonstrate that postural control is compromised in children with ALL undergoing consolidation therapy. Elevated sway speeds on firm surfaces suggest diminished balance performance, while the mixed results on foam conditions highlight difficulties with sensory integration. These preliminary observations underscore the need for targeted interventions and further research with larger samples to clarify the mechanisms behind these deficits.</div></div>","PeriodicalId":12958,"journal":{"name":"Hematology, Transfusion and Cell Therapy","volume":"47 ","pages":"Article 103884"},"PeriodicalIF":1.6000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"INVESTIGATION OF POSTURAL CONTROL IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA\",\"authors\":\"Fulya Ipek-Erdem , Sena Sonkaya , Arzu Genç , Şebnem Yılmaz\",\"doi\":\"10.1016/j.htct.2025.103884\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>Children with leukemia may face balance impairments due to somatosensory, motor, muscular, and cognitive deficits that can persist into adulthood and increase fall risk. This study aimed to evaluate postural control in children with Acute Lymphoblastic Leukemia (ALL) undergoing consolidation therapy by comparing their performance with normative data to identify potential treatment-related impairments in sensory integration and balance.</div></div><div><h3>Methodology</h3><div>Thirteen children with ALL were recruited at Dokuz Eylül University, Faculty of Physiotherapy and Rehabilitation in Turkey, and divided into two age groups: 6–7 years (n = 9) and 8–9 years (n = 4). Static balance was evaluated using the modified Clinical Test for Sensory Interaction on Balance (mCTSIB) with the Balance Master system. The test assessed postural control under four conditions: Eyes Open-firm surface (FirmEO), Eyes Closed-firm surface (FirmEC), eyes open-unstable (foam) surface (FoamEO), and eyes closed-unstable (foam) surface (FoamEC). The center of gravity's average sway speed (°/s) was measured for each condition, with higher values indicating reduced balance capability. Normative data for each condition were obtained from previous studies on healthy children.</div></div><div><h3>Results</h3><div>In the 6–7 years group, sway speeds during FirmEO and FirmEC were 0.92 s and 0.97 s, respectively, compared to norms of 0.70s and 0.92s. Under foam conditions, FoamEO reached 1.31s (norm: 1.20s), while FoamEC was 1.81s, nearly identical to the normative 1.80s. In the 8–9 years group, FirmEO was 0.55s (norm: 0.40s) and FirmEC was 0.65s (norm: 0.53s). FoamEO measured 0.82s (norm: 0.89s), whereas FoamEC was 1.70s (norm: 1.47s). Overall, these results suggest that children with ALL generally exhibit elevated sway speeds ‒ particularly under firm conditions ‒ implying impaired postural control and potential challenges in sensory integration.</div></div><div><h3>Conclusion</h3><div>Our findings demonstrate that postural control is compromised in children with ALL undergoing consolidation therapy. Elevated sway speeds on firm surfaces suggest diminished balance performance, while the mixed results on foam conditions highlight difficulties with sensory integration. These preliminary observations underscore the need for targeted interventions and further research with larger samples to clarify the mechanisms behind these deficits.</div></div>\",\"PeriodicalId\":12958,\"journal\":{\"name\":\"Hematology, Transfusion and Cell Therapy\",\"volume\":\"47 \",\"pages\":\"Article 103884\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Hematology, Transfusion and Cell Therapy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S253113792500152X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hematology, Transfusion and Cell Therapy","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S253113792500152X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"HEMATOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

目的白血病儿童可能面临躯体感觉、运动、肌肉和认知缺陷导致的平衡障碍，这些缺陷可能持续到成年，并增加跌倒的风险。本研究旨在评估接受巩固治疗的急性淋巴细胞白血病（ALL）儿童的姿势控制，通过将他们的表现与规范数据进行比较，以确定潜在的治疗相关的感觉统合和平衡障碍。方法：在土耳其Dokuz eyyl大学物理治疗和康复学院招募了13名ALL患儿，分为两个年龄组：6-7岁（n = 9）和8-9岁（n = 4）。静态平衡评估使用改进临床测试的感觉相互作用的平衡（mCTSIB）与平衡大师系统。该测试评估了四种情况下的姿势控制：眼睛张开-坚固表面（FirmEO）、眼睛闭合-坚固表面（FirmEC）、眼睛张开-不稳定（泡沫）表面（FoamEO）和眼睛闭合-不稳定（泡沫）表面（FoamEC）。测量了每种情况下重心的平均摇摆速度（°/s），数值越高表明平衡能力越差。每种情况的规范数据均来自以往对健康儿童的研究。结果6 ~ 7岁组患者在FirmEO和FirmEC期间的摇摆速度分别为0.92s和0.97 s，正常值分别为0.70s和0.92s。在发泡条件下，FoamEO达到1.31s（规范为1.20s），而FoamEC为1.81s，与规范的1.80s几乎相同。8 ~ 9岁组FirmEO为0.55s（常模0.40s）， FirmEC为0.65s（常模0.53s）。FoamEO为0.82s（规范：0.89s），而FoamEC为1.70s（规范：1.47s）。总的来说，这些结果表明ALL患儿通常表现出较高的摇摆速度，特别是在坚定的条件下，这意味着姿势控制受损和感觉统合的潜在挑战。结论：我们的研究结果表明，在接受巩固治疗的ALL儿童中，姿势控制受到损害。在坚固的表面上摇摆速度升高表明平衡性能下降，而在泡沫条件下的混合结果突出了感觉整合的困难。这些初步观察结果强调了有针对性的干预措施和更大样本的进一步研究的必要性，以阐明这些缺陷背后的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

INVESTIGATION OF POSTURAL CONTROL IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA

Objective

Children with leukemia may face balance impairments due to somatosensory, motor, muscular, and cognitive deficits that can persist into adulthood and increase fall risk. This study aimed to evaluate postural control in children with Acute Lymphoblastic Leukemia (ALL) undergoing consolidation therapy by comparing their performance with normative data to identify potential treatment-related impairments in sensory integration and balance.

Methodology

Thirteen children with ALL were recruited at Dokuz Eylül University, Faculty of Physiotherapy and Rehabilitation in Turkey, and divided into two age groups: 6–7 years (n = 9) and 8–9 years (n = 4). Static balance was evaluated using the modified Clinical Test for Sensory Interaction on Balance (mCTSIB) with the Balance Master system. The test assessed postural control under four conditions: Eyes Open-firm surface (FirmEO), Eyes Closed-firm surface (FirmEC), eyes open-unstable (foam) surface (FoamEO), and eyes closed-unstable (foam) surface (FoamEC). The center of gravity's average sway speed (°/s) was measured for each condition, with higher values indicating reduced balance capability. Normative data for each condition were obtained from previous studies on healthy children.

Results

In the 6–7 years group, sway speeds during FirmEO and FirmEC were 0.92 s and 0.97 s, respectively, compared to norms of 0.70s and 0.92s. Under foam conditions, FoamEO reached 1.31s (norm: 1.20s), while FoamEC was 1.81s, nearly identical to the normative 1.80s. In the 8–9 years group, FirmEO was 0.55s (norm: 0.40s) and FirmEC was 0.65s (norm: 0.53s). FoamEO measured 0.82s (norm: 0.89s), whereas FoamEC was 1.70s (norm: 1.47s). Overall, these results suggest that children with ALL generally exhibit elevated sway speeds ‒ particularly under firm conditions ‒ implying impaired postural control and potential challenges in sensory integration.

Conclusion

Our findings demonstrate that postural control is compromised in children with ALL undergoing consolidation therapy. Elevated sway speeds on firm surfaces suggest diminished balance performance, while the mixed results on foam conditions highlight difficulties with sensory integration. These preliminary observations underscore the need for targeted interventions and further research with larger samples to clarify the mechanisms behind these deficits.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊