Anna M Posthumus,Tim J Knobbe,Daan Kremer,Antonio W Gomes-Neto,Isabelle J C Dielwart,Jip Jonker,Caecilia S E Doorenbos,Michele F Eisenga,Marco van Londen,Rianne M Douwes,Lianne M Nieuwenhuis,Coby Annema,Marieke T de Boer,Martin H de Borst,Kevin Damman,Robert A Pol,C Tji Gan,Erik A M Verschuuren,Hans Blokzijl,Vincent E de Meijer,Stephan J L Bakker,
{"title":"移植线,一个实体器官移植受者和供者的生物库和队列研究。","authors":"Anna M Posthumus,Tim J Knobbe,Daan Kremer,Antonio W Gomes-Neto,Isabelle J C Dielwart,Jip Jonker,Caecilia S E Doorenbos,Michele F Eisenga,Marco van Londen,Rianne M Douwes,Lianne M Nieuwenhuis,Coby Annema,Marieke T de Boer,Martin H de Borst,Kevin Damman,Robert A Pol,C Tji Gan,Erik A M Verschuuren,Hans Blokzijl,Vincent E de Meijer,Stephan J L Bakker,","doi":"10.1007/s10654-025-01258-1","DOIUrl":null,"url":null,"abstract":"The TransplantLines Biobank and Cohort Study (NCT03272841) is an ongoing prospective study conducted at the University Medical Centre Groningen, The Netherlands. TransplantLines aims to identify risk factors and biomarkers associated with health problems following solid organ transplantation and donation. Additionally, the study seeks to develop new interventions to reduce symptom burden and improve long-term outcomes, including health-related quality of life, cardiovascular complications, graft failure, and mortality. It includes recipients of (combined) heart, liver, lung, kidney, pancreas, and small bowel transplants, as well as living liver and kidney donors, and deceased (multi-)organ donors. The biobank contains a wide range of biomaterials including whole blood, serum, EDTA-plasma, buffy coat, 24-h urine samples, faeces, hair, nails, and tissues. Data collection includes physical and cognitive assessments, extensive laboratory analysis, metagenomic sequencing, and questionnaires. TransplantLines, initiated in 2015, consists of 5143 participants as of October 2024, among 2312 (45%) females. The mean age was 50 (± 16) years at transplantation, 55 (± 11) years at living donation and 56 (± 15) years at deceased donation. Both cross-sectional and longitudinal biomaterials and data are included. For recipients, longitudinal biomaterials and data were collected at: pre-transplantation, at transplantation, and at 3, 6, 12, 24, and 60 months post-transplantation. For living donors, data were collected at pre-donation, donation, 3 months post-donation, and/or 5 or 10 years post-donation.","PeriodicalId":11907,"journal":{"name":"European Journal of Epidemiology","volume":"41 1","pages":""},"PeriodicalIF":5.9000,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"TransplantLines, a biobank and cohort study of solid organ transplant recipients and donors.\",\"authors\":\"Anna M Posthumus,Tim J Knobbe,Daan Kremer,Antonio W Gomes-Neto,Isabelle J C Dielwart,Jip Jonker,Caecilia S E Doorenbos,Michele F Eisenga,Marco van Londen,Rianne M Douwes,Lianne M Nieuwenhuis,Coby Annema,Marieke T de Boer,Martin H de Borst,Kevin Damman,Robert A Pol,C Tji Gan,Erik A M Verschuuren,Hans Blokzijl,Vincent E de Meijer,Stephan J L Bakker,\",\"doi\":\"10.1007/s10654-025-01258-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The TransplantLines Biobank and Cohort Study (NCT03272841) is an ongoing prospective study conducted at the University Medical Centre Groningen, The Netherlands. 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TransplantLines, a biobank and cohort study of solid organ transplant recipients and donors.
The TransplantLines Biobank and Cohort Study (NCT03272841) is an ongoing prospective study conducted at the University Medical Centre Groningen, The Netherlands. TransplantLines aims to identify risk factors and biomarkers associated with health problems following solid organ transplantation and donation. Additionally, the study seeks to develop new interventions to reduce symptom burden and improve long-term outcomes, including health-related quality of life, cardiovascular complications, graft failure, and mortality. It includes recipients of (combined) heart, liver, lung, kidney, pancreas, and small bowel transplants, as well as living liver and kidney donors, and deceased (multi-)organ donors. The biobank contains a wide range of biomaterials including whole blood, serum, EDTA-plasma, buffy coat, 24-h urine samples, faeces, hair, nails, and tissues. Data collection includes physical and cognitive assessments, extensive laboratory analysis, metagenomic sequencing, and questionnaires. TransplantLines, initiated in 2015, consists of 5143 participants as of October 2024, among 2312 (45%) females. The mean age was 50 (± 16) years at transplantation, 55 (± 11) years at living donation and 56 (± 15) years at deceased donation. Both cross-sectional and longitudinal biomaterials and data are included. For recipients, longitudinal biomaterials and data were collected at: pre-transplantation, at transplantation, and at 3, 6, 12, 24, and 60 months post-transplantation. For living donors, data were collected at pre-donation, donation, 3 months post-donation, and/or 5 or 10 years post-donation.
期刊介绍:
The European Journal of Epidemiology, established in 1985, is a peer-reviewed publication that provides a platform for discussions on epidemiology in its broadest sense. It covers various aspects of epidemiologic research and statistical methods. The journal facilitates communication between researchers, educators, and practitioners in epidemiology, including those in clinical and community medicine. Contributions from diverse fields such as public health, preventive medicine, clinical medicine, health economics, and computational biology and data science, in relation to health and disease, are encouraged. While accepting submissions from all over the world, the journal particularly emphasizes European topics relevant to epidemiology. The published articles consist of empirical research findings, developments in methodology, and opinion pieces.