Patryk Filipiak, Kamri Clarke, Timothy M Shepherd, Mary Bruno, Dimitris G Placantonakis, Steven H Baete
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Anisotropy boosting improves ODF-Fingerprinting tractography in edematous brain.
Peritumoral vasogenic edema of the brain is a major confounding factor for diffusion MRI tractography. Excessive fluids accumulated in edematous white matter decrease anisotropy of water self-diffusion which affects tracking algorithms. We address this hurdle with ODF-Fingerprinting (ODF-FP) - a dictionary-based fiber reconstruction algorithm that accommodates variability of neural tissue. By adding a regularization term to the ODF-FP matching formula, we boost diffusion anisotropy to improve white matter fiber identification in edematous regions.
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