不同晶状体疾病的前段特征及空间变异。

IF 2.6 3区 医学 Q2 ONCOLOGY
Jianxia Fang , Ce Shi , Xinyu Ma , Siting Sheng, Jingwei Xu, Sha Zhu, Yixuan Feng, Yu Zhang, Lirui Liu, Huiling Zhao, Zhe Xu, Wen Xu
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引用次数: 0

摘要

前言:应用三种前房成像仪器评估白内障、晶状体半脱位(LS)和微球晶状体(MSP)患者的前房和晶状体形态,并建立一种通过前房形态学测量评估晶状体位置空间特征的新方法。方法:采用光学相干断层扫描(AS- oct)、超声生物显微镜(UBM)和IOLMaster700对98只眼(正常眼19只,白内障眼25只,裸眼27只,MSP眼27只)进行检查。测量包括角膜厚度、前房参数和晶状体厚度(LT)。我们引入前房角(ACA)和角开距(AOD)的变异系数(CV)来量化晶状体脱位,并利用AS-OCT和UBM生成晶状体位置改变图来可视化晶状体脱位的程度和分布。结果:LS组和MSP组LT明显高于正常组和白内障组(P < 0.05)。LS组和MSP组鼻部AOD减小,MSP组鼻部AOD小于正常组(P < 0.05)。LS组颞叶ACA明显低于其他组(P < 0.05)。MSP组ACA和AOD的AS-OCT测量值超过UBM值。CV测量和晶状体位置变化图有效地说明了晶状体错位和晶状体弱的程度。结论:各病例均表现出明显的AS特征。ACA和AOD的CV,以及宽视场as - oct和UBM的位置改变图,可能作为诊断晶状体脱位相关疾病、识别脱位区域和评估晶状体弱的有价值的工具。试验注册号:NCT04833491 (ClinicalTrials.gov.)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anterior segment characteristics and spatial variations of different crystalline lens diseases

Introduction

To evaluate anterior chamber and crystalline lens morphology in patients with cataracts, lens subluxation (LS), and microspherophakia (MSP) using three anterior segment (AS) imaging instruments, and to develop a novel method for assessing the spatial characteristics of crystalline lens position through anterior chamber morphology measurements.

Methods

We examined 98 eyes (19 normal, 25 cataracts, 27 LS, 27 MSP) using AS optical coherence tomography (AS-OCT), ultrasound biomicroscopy (UBM), and IOLMaster700. Measurements included corneal thickness, anterior chamber parameters, and lens thickness (LT). We introduced the coefficient of variation (CV) of anterior chamber angle (ACA) and angle open distance (AOD) to quantify lens dislocation, and generated lens position alteration maps using AS-OCT and UBM to visualize the extent and distribution of lens dislocation.

Results

The LS and MSP groups showed significantly greater LT compared to normal and cataract groups (P < 0.05). The nasal ACA was reduced in LS and MSP groups, with MSP showing smaller nasal AOD compared to normal group (P < 0.05). Temporal ACA was significantly lower in the LS group compared to other groups (P < 0.05). AS-OCT measurements of ACA and AOD in the MSP group exceeded UBM values. The CV measurements and lens location alterations maps effectively illustrated the extent of lens dislocation and zonular weakness.

Conclusion

Each condition showed distinct AS features. The CV of ACA and AOD, along with location alteration maps from wide-field AS-OCT and UBM, might serve as valuable tools in diagnosing lens dislocation-related diseases, identifying dislocation areas, and assessing zonular weakness.
Trial registration number: NCT04833491 (ClinicalTrials.gov.)
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来源期刊
CiteScore
5.80
自引率
24.20%
发文量
509
审稿时长
50 days
期刊介绍: Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.
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