出生时患有先天性肾和尿路(CAKUT)异常的婴儿的母亲危险因素:横断面评估。

Mymensingh medical journal : MMJ Pub Date : 2025-07-01
N Akand, P K Sarkar, M J Alam, M Rahman, T Tabassum, B Chowdhury, M Hanif
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摘要

先天性肾和尿路异常(先天性肾和尿路异常)常导致肾功能衰竭。尽管对CAKUT的病理生理机制仍不完全了解,但迄今为止已确定了与CAKUT患儿相关的几个母体危险因素。因此,本研究的目的是评估患CAKUT婴儿的母亲的危险因素比例。这项横断面研究于2018年5月至2018年11月在孟加拉国达卡Shishu医院的儿科、儿科肾病科、新生儿科和儿科泌尿科进行了为期6个月的研究。本研究共纳入200例年龄≤60天且确诊为CAKUT的婴儿。被告知的提升是从孩子的父母那里被夺走的。采用半结构化问卷进行数据收集,采用SPSS 21.0版本进行统计分析。这项研究是结合《赫尔辛基宣言》的伦理原则进行的。CAKUT患儿平均年龄为22.25±15.08 (SD) d,男女比例为1:1。表现为原发性膀胱输尿管反流(38.0%)、盆腔输尿管交界处梗阻(20.0%)、肾脏发育不全(16.0%)、后尿道瓣膜(12.0%)、肾脏发育不良(10.0%)和多囊性肾发育不良(3.5%)。最常见的妊娠危险因素为体重过重(76.0%)、糖尿病(32.5%)和高血压(29.5%)。羊水过少(87.5%)、妊娠期糖尿病(67.0%)和妊娠期高血压(45.5%)是最常见的妊娠危险因素。孕妇孕期超重、孕妇糖尿病和羊水过少是最常见的危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Maternal Risk Factors for Infants Born with Congenital Renal and Urinary Tract (CAKUT) Anomalies: A Cross-Sectional Assessment.

Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) often results in renal failure. Alhough the pathophysiology of CAKUT is still not completely understood, several maternal risk factors have been identified associated with children with CAKUT so far. Therefore, the aim of this study was to assess the proportion of risk factors of mothers gave birth to the infants with CAKUT. This cross-sectional study was conducted over a six-month period in the Departments of Pediatrics, Pediatric Nephrology, Neonatology and Pediatric Urology in Dhaka Shishu Hospital, Bangladesh from May 2018 to November 2018. A total of 200 infants aged ≤60 days and with a confirmed diagnosis of CAKUT were included in this study. Informed ascend was taken from the parents of the child. A semi-structured questionnaire was used for data collection, and statistical analysis was performed using SPSS version 21.0. This research was undertaken in conjunction with the ethical principles of Declaration of Helsinki. The mean age of the infants with CAKUT was 22.25±15.08 (SD) days with a male to female ratio of 1:1. The presenting anomalies were primary vesico-ureteral reflux (38.0%), pelvi-ureteric junction obstruction (20.0%), agenesis of the kidney (16.0%), posterior urethral valve (12.0%), dysplasia of the kidney (10.0%) and multicystic dysplastic kidney (3.5%). The most common pregestational risk factors were overweight (76.0%), diabetes mellitus (32.5%) and hypertension (29.5%) among the mothers. On the other hand, oligohydramnios (87.5%), gestational diabetes mellitus (67.0%) and gestational hypertension (45.5%) were the most frequently identified gestational risk factors. Pregestational overweight in women, maternal diabetes and oligohydramnios were most commonly identified risk factors among the mothers of CAKUT infant.

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