聚乙二醇化W4.6N4/WO3纳米颗粒作为近红外光热剂用于有效的癌症治疗。

Journal of materials chemistry. B Pub Date : 2025-06-30 DOI:10.1039/d5tb00665a

Rui Yang, Jianping Li, Hao Song, Cong Wang, Na Xu

{"title":"聚乙二醇化W4.6N4/WO3纳米颗粒作为近红外光热剂用于有效的癌症治疗。","authors":"Rui Yang, Jianping Li, Hao Song, Cong Wang, Na Xu","doi":"10.1039/d5tb00665a","DOIUrl":null,"url":null,"abstract":"In recent years, near-infrared (NIR) light-sensitive photothermal agents (PTAs) with excellent photothermal conversion efficiency have shown great potential in enhancing the performance of advanced photothermal therapy (PTT). In this study, polyethylene glycol (PEG)-modified tungsten nitride/tungsten oxide nanoparticles (PEGylated W4.6N4/WO3-NPs) with heterojunction structures were designed and constructed. The PEGylated W4.6N4/WO3-NPs showed strong absorbance ability in the NIR window and photothermal conversion under 808 nm irradiation. The PEGylated W4.6N4/WO3-NPs exhibited good biocompatibility and efficient tumor ablation function. Therefore, the PEGylated W4.6N4/WO3-NPs can be used as a photothermal agent.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"PEGylated W4.6N4/WO3 nanoparticles as a near-infrared photothermal agent for effective cancer therapy.\",\"authors\":\"Rui Yang, Jianping Li, Hao Song, Cong Wang, Na Xu\",\"doi\":\"10.1039/d5tb00665a\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In recent years, near-infrared (NIR) light-sensitive photothermal agents (PTAs) with excellent photothermal conversion efficiency have shown great potential in enhancing the performance of advanced photothermal therapy (PTT). In this study, polyethylene glycol (PEG)-modified tungsten nitride/tungsten oxide nanoparticles (PEGylated W4.6N4/WO3-NPs) with heterojunction structures were designed and constructed. The PEGylated W4.6N4/WO3-NPs showed strong absorbance ability in the NIR window and photothermal conversion under 808 nm irradiation. The PEGylated W4.6N4/WO3-NPs exhibited good biocompatibility and efficient tumor ablation function. Therefore, the PEGylated W4.6N4/WO3-NPs can be used as a photothermal agent.\",\"PeriodicalId\":94089,\"journal\":{\"name\":\"Journal of materials chemistry. B\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of materials chemistry. B\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1039/d5tb00665a\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of materials chemistry. B","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1039/d5tb00665a","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

近年来，具有良好光热转换效率的近红外（NIR）光敏光热剂（PTAs）在提高先进光热治疗（PTT）性能方面显示出巨大潜力。本研究设计并构建了具有异质结结构的聚乙二醇修饰的氮化钨/氧化钨纳米粒子（聚乙二醇化的W4.6N4/WO3-NPs）。聚乙二醇化的W4.6N4/WO3-NPs在808 nm辐照下具有较强的近红外窗口吸收能力和光热转换能力。聚乙二醇化的W4.6N4/WO3-NPs具有良好的生物相容性和有效的肿瘤消融功能。因此，聚乙二醇化的W4.6N4/WO3-NPs可以用作光热剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

PEGylated W_4.6N₄/WO₃ nanoparticles as a near-infrared photothermal agent for effective cancer therapy.

In recent years, near-infrared (NIR) light-sensitive photothermal agents (PTAs) with excellent photothermal conversion efficiency have shown great potential in enhancing the performance of advanced photothermal therapy (PTT). In this study, polyethylene glycol (PEG)-modified tungsten nitride/tungsten oxide nanoparticles (PEGylated W_4.6N₄/WO₃-NPs) with heterojunction structures were designed and constructed. The PEGylated W_4.6N₄/WO₃-NPs showed strong absorbance ability in the NIR window and photothermal conversion under 808 nm irradiation. The PEGylated W_4.6N₄/WO₃-NPs exhibited good biocompatibility and efficient tumor ablation function. Therefore, the PEGylated W_4.6N₄/WO₃-NPs can be used as a photothermal agent.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of materials chemistry. B 化学科学, 工程与材料, 生命科学, 分析化学, 高分子组装与超分子结构, 高分子科学, 免疫生物学, 免疫学, 生化分析及生物传感, 组织工程学, 生物力学与组织工程学, 资源循环科学, 冶金与矿业, 生物医用高分子材料, 有机高分子材料, 金属材料的制备科学与跨学科应用基础, 金属材料, 样品前处理方法与技术, 有机分子功能材料化学, 有机化学

CiteScore

12.00

自引率

0.00%

发文量

审稿时长

1 months