基于7T磁共振成像的3型脊髓小脑性共济失调患者乳腺体结构与认知功能障碍的相关性研究

IF 2.9
Psychoradiology Pub Date : 2025-06-19 eCollection Date: 2025-01-01 DOI:10.1093/psyrad/kkaf010
Congwei Li, Yunsong Peng, Peiling Ou, Ru Wen, Wei Chen, Chong Tian, Zhiming Zhen, Xingang Wang, Lan Ou, Chen Liu, Bijia Wang
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引用次数: 0

摘要

背景:脊髓小脑共济失调3型(SCA3)是一种以小脑萎缩和运动功能障碍为特征的遗传性疾病。患者还表现出非共济失调症状,如认知障碍。虽然先前的神经影像学研究已经在SCA3患者中发现了多个与认知相关的大脑区域,但对Papez电路结构损伤(例如,乳状体(mb))的研究仍然很少。7T磁共振成像(MRI)技术的进步使扫描和定量分析结构成为可能,如Papez电路中的mb。在这项研究中,我们研究了SCA3患者的认知功能障碍与三个Papez电路结构的变化之间的关系:MBs、乳丘束(MTT)和联合后穹窿(PF)。方法:本横断面研究纳入46例SCA3患者和48例健康对照,接受7T MRI和神经心理学评估。使用手动描述和深度学习模型,我们从参与者中提取了MB, MTT和PF卷。随后,对定量数据进行统计分析。结果:与健康对照组相比,SCA3患者表现出MB、PF和MTT体积的减少。认知损伤组的MB、左MTT和左PF体积明显低于认知保留组。SCA3患者的认知功能与MB、左侧MTT和左侧PF呈正相关,而运动功能与MB和左侧PF呈负相关。结论:SCA3患者认知记忆功能下降与MB、MTT和PF的改变相关,且在左侧更为明显。运动功能障碍可能与认知障碍的发展有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
7T magnetic resonance imaging-based investigation of the correlation between mammillary body structure and cognitive impairment in patients with spinocerebellar ataxia type 3.

Background: Spinocerebellar ataxia type 3 (SCA3) is a hereditary disease characterized by cerebellar atrophy and motor dysfunction. Patients also exhibit non-ataxic symptoms such as cognitive impairment. While prior neuroimaging studies have identified multiple cognition-associated brain regions in SCA3 patients, research on Papez circuit structural damage (e.g., mammillary bodies (MBs)) remains sparse. Advancements in 7T magnetic resonance imaging (MRI) technology have enabled scanning and quantitative analysis of structures such as the MBs within the Papez circuit. In this study, we investigated the relationship between cognitive impairment in patients with SCA3 and structural changes in the three Papez circuit structures: the MBs, the mammillothalamic tract (MTT), and the post-commissural fornix (PF).

Methods: This cross-sectional study included 46 SCA3 patients and 48 healthy controls undergoing 7T MRI and neuropsychological assessments. Using manual delineation and a deep learning model, we extracted the MB, MTT, and PF volumes from participants. Subsequently, we statistically analyzed the quantitative data.

Results: SCA3 patients exhibited reduced MB, PF, and MTT volumes compared with those of the healthy controls. The MB, left MTT, and left PF volumes were significantly lower in cognitive impairment than in cognitive preserved. Cognitive function in SCA3 patients was positively correlated with the MB, left MTT, and left PF, whereas motor function was negatively correlated with the MB and left PF.

Conclusion: Decreased cognitive and memory function in SCA3 patients is associated with MB, MTT, and PF alterations and is more pronounced on the left side. Motor dysfunction may be correlated with cognitive impairment development.

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