Kavitha Prasad, A Nityasri, Jugal Ashok Toprani, Shashank Madhusudan
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Effects of close surgical margins on prognosis and recurrence of oral squamous cell carcinoma.
Objectives: To assess the relationships of close surgical margins with recurrence and prognosis of oral squamous cell carcinoma (OSCC).
Materials and methods: This retrospective study consisted of 198 patients who were diagnosed with OSCC based on histopathology. All patients underwent wide local tumor resection and neck dissection, followed by or preceded by chemotherapy and/or radiotherapy. The tumor variables assessed were the pathological stage of disease, involvement site, tumor size, margin status, tumor differentiation, bone involvement if any, presence of lymphovascular or perineural invasion, adjuvant therapies including chemotherapy and radiotherapy, lymph node involvement, and ratio.
Results: The outcome of the disease based on margins was statistically significant, with close mar- gins associated with increased risk of disease fatality. Recurrence was associated with close margins, followed by adequate margins, and the relation-ship was significant within the first 2 years. Tumor stage and size significantly correlated with margin status. Close surgical margins correlated with one positive lymph node.
Conclusion: Close surgical margins are strong predictors for determining prognosis of OSCC.
期刊介绍：
Journal of the Korean Association of Oral and Maxillofacial Surgeons (J Korean Assoc Oral Maxillofac Surg) is the official journal of the Korean Association of Oral and Maxillofacial Surgeons. This bimonthly journal offers high-quality original articles, case series study, case reports, collective or current reviews, technical notes, brief communications or correspondences, and others related to regenerative medicine, dentoalveolar surgery, dental implant surgery, head and neck cancer, aesthetic facial surgery/orthognathic surgery, facial injuries, temporomandibular joint disorders, orofacial disease, and oral pathology. J Korean Assoc Oral Maxillofac Surg is of interest to oral and maxillofacial surgeons and dental practitioners as well as others who are interested in these fields.
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