{"title":"颌骨非药物相关性骨坏死与药物相关性骨坏死的比较：一项初步研究。","authors":"Ilgin Ari, Ecem Usman, Selen Adiloğlu, Alper Aktaş","doi":"10.5125/jkaoms.2025.51.3.151","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to compare composite radiographic index (CRI-index) findings of medication-related osteonecrosis of jaws (MRONJs) and non-medication related osteonecrosis of jaws (n-MRONJs) and predict factors predictive of recurrence and healing delays.</p><p><strong>Materials and methods: </strong>Patients referred to our clinic for stage 2 and 3 MRONJ and n-MRONJ between 2020 and 2023 were included in this study. Microorganisms were isolated in samples of excised bone obtained from the adjacent bone by surgery. CRI-index was evaluated using radiological data. Patient age, sex, causes and localization of osteomyelitis, as well as intraoperative and postoperative complications were recorded.</p><p><strong>Results: </strong>There were no statistically significant differences in CRI-index score between the two groups (<i>P</i>>0.05). Presence of <i>actinomyces</i> colonies was not a significant predictor of recurrence or healing status. Furthermore, the presence of <i>actinomyces</i> colonies was not predictive of recurrence in the MRONJ group (<i>P</i>=0.035); however, the use of the antiresorptive agent denasumab was found to be a risk factor for recurrence in the MRONJ group (<i>P</i>=0.035).</p><p><strong>Conclusion: </strong>Radiological and clinical findings were similar for MRONJ and n-MRONJ patients. However, although treatment methods for these two groups is almost identical, the follow-up process can vary. <i>Actinomyces</i> presence was not a predictive factor for recurrence of any type of osteonecrosis. To predict recurrence and healing delays, more parameters need to be investigated.</p>","PeriodicalId":51711,"journal":{"name":"Journal of the Korean Association of Oral and Maxillofacial Surgeons","volume":"51 3","pages":"151-160"},"PeriodicalIF":1.4000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223437/pdf/","citationCount":"0","resultStr":"{\"title\":\"Comparison of non-medication-related osteonecrosis and medication-related osteonecrosis of the jaw: a pilot study.\",\"authors\":\"Ilgin Ari, Ecem Usman, Selen Adiloğlu, Alper Aktaş\",\"doi\":\"10.5125/jkaoms.2025.51.3.151\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This study aimed to compare composite radiographic index (CRI-index) findings of medication-related osteonecrosis of jaws (MRONJs) and non-medication related osteonecrosis of jaws (n-MRONJs) and predict factors predictive of recurrence and healing delays.</p><p><strong>Materials and methods: </strong>Patients referred to our clinic for stage 2 and 3 MRONJ and n-MRONJ between 2020 and 2023 were included in this study. Microorganisms were isolated in samples of excised bone obtained from the adjacent bone by surgery. CRI-index was evaluated using radiological data. Patient age, sex, causes and localization of osteomyelitis, as well as intraoperative and postoperative complications were recorded.</p><p><strong>Results: </strong>There were no statistically significant differences in CRI-index score between the two groups (<i>P</i>>0.05). Presence of <i>actinomyces</i> colonies was not a significant predictor of recurrence or healing status. Furthermore, the presence of <i>actinomyces</i> colonies was not predictive of recurrence in the MRONJ group (<i>P</i>=0.035); however, the use of the antiresorptive agent denasumab was found to be a risk factor for recurrence in the MRONJ group (<i>P</i>=0.035).</p><p><strong>Conclusion: </strong>Radiological and clinical findings were similar for MRONJ and n-MRONJ patients. However, although treatment methods for these two groups is almost identical, the follow-up process can vary. <i>Actinomyces</i> presence was not a predictive factor for recurrence of any type of osteonecrosis. To predict recurrence and healing delays, more parameters need to be investigated.</p>\",\"PeriodicalId\":51711,\"journal\":{\"name\":\"Journal of the Korean Association of Oral and Maxillofacial Surgeons\",\"volume\":\"51 3\",\"pages\":\"151-160\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223437/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Korean Association of Oral and Maxillofacial Surgeons\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5125/jkaoms.2025.51.3.151\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Korean Association of Oral and Maxillofacial Surgeons","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5125/jkaoms.2025.51.3.151","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Comparison of non-medication-related osteonecrosis and medication-related osteonecrosis of the jaw: a pilot study.
Objectives: This study aimed to compare composite radiographic index (CRI-index) findings of medication-related osteonecrosis of jaws (MRONJs) and non-medication related osteonecrosis of jaws (n-MRONJs) and predict factors predictive of recurrence and healing delays.
Materials and methods: Patients referred to our clinic for stage 2 and 3 MRONJ and n-MRONJ between 2020 and 2023 were included in this study. Microorganisms were isolated in samples of excised bone obtained from the adjacent bone by surgery. CRI-index was evaluated using radiological data. Patient age, sex, causes and localization of osteomyelitis, as well as intraoperative and postoperative complications were recorded.
Results: There were no statistically significant differences in CRI-index score between the two groups (P>0.05). Presence of actinomyces colonies was not a significant predictor of recurrence or healing status. Furthermore, the presence of actinomyces colonies was not predictive of recurrence in the MRONJ group (P=0.035); however, the use of the antiresorptive agent denasumab was found to be a risk factor for recurrence in the MRONJ group (P=0.035).
Conclusion: Radiological and clinical findings were similar for MRONJ and n-MRONJ patients. However, although treatment methods for these two groups is almost identical, the follow-up process can vary. Actinomyces presence was not a predictive factor for recurrence of any type of osteonecrosis. To predict recurrence and healing delays, more parameters need to be investigated.
期刊介绍：
Journal of the Korean Association of Oral and Maxillofacial Surgeons (J Korean Assoc Oral Maxillofac Surg) is the official journal of the Korean Association of Oral and Maxillofacial Surgeons. This bimonthly journal offers high-quality original articles, case series study, case reports, collective or current reviews, technical notes, brief communications or correspondences, and others related to regenerative medicine, dentoalveolar surgery, dental implant surgery, head and neck cancer, aesthetic facial surgery/orthognathic surgery, facial injuries, temporomandibular joint disorders, orofacial disease, and oral pathology. J Korean Assoc Oral Maxillofac Surg is of interest to oral and maxillofacial surgeons and dental practitioners as well as others who are interested in these fields.
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