Melvin Gerardy, Alain Gaudric, Pierre Duraffour, Vanessa Sentis, Francine Behar-Cohen, Nathalie Costedoat Chalumeau, Véronique Le Guern, Nathalie Morel, Vincent Soler, Elodie Bousquet
{"title":"灾难性抗磷脂综合征患者的脉络膜缺血：一个病例系列。","authors":"Melvin Gerardy, Alain Gaudric, Pierre Duraffour, Vanessa Sentis, Francine Behar-Cohen, Nathalie Costedoat Chalumeau, Véronique Le Guern, Nathalie Morel, Vincent Soler, Elodie Bousquet","doi":"10.1097/ICB.0000000000001779","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To report three cases of acute choroidal ischemia in patients diagnosed with catastrophic antiphospholipid syndrome (CAPS).</p><p><strong>Methods: </strong>The medical and imaging records of patients with CAPS were retrospectively reviewed. Patients underwent retinal imaging, including fundus photography, spectral-domain optical coherence tomography (SD-OCT), fluorescein and indocyanine green angiography.</p><p><strong>Results: </strong>This report summarizes three cases of pregnant women (six eyes) with CAPS and posterior ocular involvement. SD-OCT revealed multiple subretinal detachments. Fluorescein and indocyanine green angiography showed triangular non-perfused areas consistent with Amalric triangular choroidal infarction and multiple spots of subretinal leakage. Patients were hospitalized in intensive care unit for treatment with corticosteroids, anticoagulants and plasma exchanges/intravenous immunoglobulins. Full recovery was observed in all cases.</p><p><strong>Conclusion: </strong>The presence of acute choroidal ischemia in patients with antiphospholipid syndrome should alert ophthalmologists to the possibility of CAPS, which is a life-threatening disease. Patients should immediately be referred to a specialist.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Choroidal Ischemia in patients with Catastrophic Antiphospholipid Syndrome: a case series.\",\"authors\":\"Melvin Gerardy, Alain Gaudric, Pierre Duraffour, Vanessa Sentis, Francine Behar-Cohen, Nathalie Costedoat Chalumeau, Véronique Le Guern, Nathalie Morel, Vincent Soler, Elodie Bousquet\",\"doi\":\"10.1097/ICB.0000000000001779\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To report three cases of acute choroidal ischemia in patients diagnosed with catastrophic antiphospholipid syndrome (CAPS).</p><p><strong>Methods: </strong>The medical and imaging records of patients with CAPS were retrospectively reviewed. Patients underwent retinal imaging, including fundus photography, spectral-domain optical coherence tomography (SD-OCT), fluorescein and indocyanine green angiography.</p><p><strong>Results: </strong>This report summarizes three cases of pregnant women (six eyes) with CAPS and posterior ocular involvement. SD-OCT revealed multiple subretinal detachments. Fluorescein and indocyanine green angiography showed triangular non-perfused areas consistent with Amalric triangular choroidal infarction and multiple spots of subretinal leakage. Patients were hospitalized in intensive care unit for treatment with corticosteroids, anticoagulants and plasma exchanges/intravenous immunoglobulins. Full recovery was observed in all cases.</p><p><strong>Conclusion: </strong>The presence of acute choroidal ischemia in patients with antiphospholipid syndrome should alert ophthalmologists to the possibility of CAPS, which is a life-threatening disease. Patients should immediately be referred to a specialist.</p>\",\"PeriodicalId\":53580,\"journal\":{\"name\":\"Retinal Cases and Brief Reports\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-06-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Retinal Cases and Brief Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/ICB.0000000000001779\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Retinal Cases and Brief Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/ICB.0000000000001779","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Choroidal Ischemia in patients with Catastrophic Antiphospholipid Syndrome: a case series.
Purpose: To report three cases of acute choroidal ischemia in patients diagnosed with catastrophic antiphospholipid syndrome (CAPS).
Methods: The medical and imaging records of patients with CAPS were retrospectively reviewed. Patients underwent retinal imaging, including fundus photography, spectral-domain optical coherence tomography (SD-OCT), fluorescein and indocyanine green angiography.
Results: This report summarizes three cases of pregnant women (six eyes) with CAPS and posterior ocular involvement. SD-OCT revealed multiple subretinal detachments. Fluorescein and indocyanine green angiography showed triangular non-perfused areas consistent with Amalric triangular choroidal infarction and multiple spots of subretinal leakage. Patients were hospitalized in intensive care unit for treatment with corticosteroids, anticoagulants and plasma exchanges/intravenous immunoglobulins. Full recovery was observed in all cases.
Conclusion: The presence of acute choroidal ischemia in patients with antiphospholipid syndrome should alert ophthalmologists to the possibility of CAPS, which is a life-threatening disease. Patients should immediately be referred to a specialist.
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