Christian Zeta-Arica, Lucia Galarreta-Galvez, Fernando Revoredo-Rego, Fritz Kometter-Barrios, Jose Arenas-Gamio
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Signet ring cell carcinoma of the ampulla of Vater: case series.
Signet ring cell carcinomas (SRCC) are aggressive neoplasms with poor prognoses, commonly found in the stomach, colon, and small intestine. However, their occurrence in the Ampulla of Vater is rare and their origin remains unclear. Among 163 cases of surgically treated ampullary carcinomas, we observed 4 cases (2.4%) of SRCC with jaundice being the primary clinical manifestation, followed by weight loss and abdominal pain. Duodenoscopy played a pivotal role in the diagnosis. Anatomopathological findings are detailed, emphasizing immuno-histological lineage and lymph node involvement. Two cases underwent adjuvant treatment (GemCap and Folfirinox), with follow-up periods ranging from 18 to 64 months. We review the literature, highlighting the importance of radical surgery, lymph node involvement, and systemic treatment in the survival of these patients.
期刊介绍：
Oxford Medical Case Reports (OMCR) is an open access, peer-reviewed online journal publishing original and educationally valuable case reports that expand the field of medicine. The journal covers all medical specialities including cardiology, rheumatology, nephrology, oncology, neurology, and reproduction, comprising a comprehensive resource for physicians in all fields and at all stages of training. Oxford Medical Case Reports deposits all articles in PubMed Central (PMC). Physicians and researchers can find your work through PubMed , helping you reach the widest possible audience. The journal is also indexed in the Web of Science Core Collection . Oxford Medical Case Reports publishes case reports under the following categories: Allergy Audiovestibular medicine Cardiology and cardiovascular systems Critical care medicine Dermatology Emergency medicine Endocrinology and metabolism Gastroenterology and hepatology Geriatrics and gerontology Haematology Immunology Infectious diseases and tropical medicine Medical disorders in pregnancy Medical ophthalmology Nephrology Neurology Oncology Paediatrics Pain Palliative medicine Pharmacology and pharmacy Psychiatry Radiology, nuclear medicine, and medical imaging Respiratory disorders Rheumatology Sexual and reproductive health Sports Medicine Substance abuse.
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