{"title":"一例角膜脓肿后自我用药与局部皮肤皮质类固醇在一个孩子。","authors":"Firdaouss Essaddouqui Esslimani, Chaimae Khodriss, Soukaina Zefzoufi, Soukayna Kabbou, Meriem El Bahloul","doi":"10.1093/omcr/omaf064","DOIUrl":null,"url":null,"abstract":"<p><p>Topical dermatologic corticosteroids (TDC), while essential in treating skin conditions, can cause severe complications when misused, particularly in children. This case study reports a 7-year-old girl with a history of long-term self-medication with 0.05% betamethasone for dermatological lesions, resulting in iatrogenic Cushing's syndrome and a severe corneal abscess. The child presented with visual loss, corneal infiltrates, and hypopyon. Ocular and biochemical tests confirmed the diagnosis. The management included antifungal and antibacterial treatments, intrastromal voriconazole injection, and amniotic membrane grafting. TDC were gradually discontinued, and tacrolimus was used for skin symptoms. After 3 months, visual acuity improved to 3/10, with residual corneal opacity. This case emphasizes the dangers of prolonged TDC use without supervision and the need for early intervention in ocular complications.</p>","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 6","pages":"omaf064"},"PeriodicalIF":0.4000,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202287/pdf/","citationCount":"0","resultStr":"{\"title\":\"A case of corneal abscess following self-medication with topical dermatologic corticosteroids in a child.\",\"authors\":\"Firdaouss Essaddouqui Esslimani, Chaimae Khodriss, Soukaina Zefzoufi, Soukayna Kabbou, Meriem El Bahloul\",\"doi\":\"10.1093/omcr/omaf064\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Topical dermatologic corticosteroids (TDC), while essential in treating skin conditions, can cause severe complications when misused, particularly in children. This case study reports a 7-year-old girl with a history of long-term self-medication with 0.05% betamethasone for dermatological lesions, resulting in iatrogenic Cushing's syndrome and a severe corneal abscess. The child presented with visual loss, corneal infiltrates, and hypopyon. Ocular and biochemical tests confirmed the diagnosis. The management included antifungal and antibacterial treatments, intrastromal voriconazole injection, and amniotic membrane grafting. TDC were gradually discontinued, and tacrolimus was used for skin symptoms. After 3 months, visual acuity improved to 3/10, with residual corneal opacity. This case emphasizes the dangers of prolonged TDC use without supervision and the need for early intervention in ocular complications.</p>\",\"PeriodicalId\":45318,\"journal\":{\"name\":\"Oxford Medical Case Reports\",\"volume\":\"2025 6\",\"pages\":\"omaf064\"},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2025-06-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202287/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oxford Medical Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/omcr/omaf064\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oxford Medical Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/omcr/omaf064","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
A case of corneal abscess following self-medication with topical dermatologic corticosteroids in a child.
Topical dermatologic corticosteroids (TDC), while essential in treating skin conditions, can cause severe complications when misused, particularly in children. This case study reports a 7-year-old girl with a history of long-term self-medication with 0.05% betamethasone for dermatological lesions, resulting in iatrogenic Cushing's syndrome and a severe corneal abscess. The child presented with visual loss, corneal infiltrates, and hypopyon. Ocular and biochemical tests confirmed the diagnosis. The management included antifungal and antibacterial treatments, intrastromal voriconazole injection, and amniotic membrane grafting. TDC were gradually discontinued, and tacrolimus was used for skin symptoms. After 3 months, visual acuity improved to 3/10, with residual corneal opacity. This case emphasizes the dangers of prolonged TDC use without supervision and the need for early intervention in ocular complications.
期刊介绍：
Oxford Medical Case Reports (OMCR) is an open access, peer-reviewed online journal publishing original and educationally valuable case reports that expand the field of medicine. The journal covers all medical specialities including cardiology, rheumatology, nephrology, oncology, neurology, and reproduction, comprising a comprehensive resource for physicians in all fields and at all stages of training. Oxford Medical Case Reports deposits all articles in PubMed Central (PMC). Physicians and researchers can find your work through PubMed , helping you reach the widest possible audience. The journal is also indexed in the Web of Science Core Collection . Oxford Medical Case Reports publishes case reports under the following categories: Allergy Audiovestibular medicine Cardiology and cardiovascular systems Critical care medicine Dermatology Emergency medicine Endocrinology and metabolism Gastroenterology and hepatology Geriatrics and gerontology Haematology Immunology Infectious diseases and tropical medicine Medical disorders in pregnancy Medical ophthalmology Nephrology Neurology Oncology Paediatrics Pain Palliative medicine Pharmacology and pharmacy Psychiatry Radiology, nuclear medicine, and medical imaging Respiratory disorders Rheumatology Sexual and reproductive health Sports Medicine Substance abuse.
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