推进白血病诊断和治疗:世卫组织在非洲支持的实验室创新——叙述性回顾。

IF 3.9 Q2 ONCOLOGY
Blood and Lymphatic Cancer-Targets and Therapy Pub Date : 2025-06-24 eCollection Date: 2025-01-01 DOI:10.2147/BLCTT.S518005
Emmanuel Ifeanyi Obeagu
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引用次数: 0

摘要

在非洲,白血病仍然是一个重大的健康挑战,在那里,获得先进诊断技术的机会有限,往往导致诊断延迟和治疗效果欠佳。本综述探讨了世卫组织支持的实验室创新在促进整个非洲大陆白血病诊断方面的作用。报告探讨了分子诊断、流式细胞术和细胞遗传学等关键技术,强调了这些创新如何在资源有限的情况下提高白血病检测的准确性和速度。通过促进早期和精确诊断,这些技术正在改善患者管理和治疗结果。尽管取得了有希望的进展,但广泛实施的重大障碍仍然存在,包括成本高、基础设施不足和训练有素的人员短缺。世卫组织通过区域合作、技术援助和能力建设举措应对这些挑战的努力对于克服这些障碍至关重要。建立专门的诊断中心和将先进技术整合到国家卫生保健系统中是扩大非洲白血病治疗机会和改善白血病治疗的关键战略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advancing Leukemia Diagnosis and Treatment: WHO-Supported Laboratory Innovations in Africa- A Narrative Review.

Leukemia remains a major health challenge in Africa, where limited access to advanced diagnostic technologies often leads to delayed diagnosis and suboptimal treatment outcomes. This review explores the role of WHO-supported laboratory innovations in advancing leukemia diagnosis across the continent. It examines key technologies such as molecular diagnostics, flow cytometry, and cytogenetics, highlighting how these innovations have enhanced the accuracy and speed of leukemia detection in resource-limited settings. By facilitating early and precise diagnoses, these technologies are improving patient management and treatment outcomes. Despite the promising advancements, significant barriers to widespread implementation persist, including high costs, inadequate infrastructure, and a shortage of trained personnel. WHO's efforts to address these challenges through regional collaborations, technical assistance, and capacity-building initiatives are pivotal in overcoming these obstacles. The establishment of specialized diagnostic centers and the integration of advanced technologies into national healthcare systems are key strategies to expand access and improve leukemia care in Africa.

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来源期刊
自引率
7.10%
发文量
16
审稿时长
16 weeks
期刊介绍: Blood and Lymphatic Cancer: Targets and Therapy is an international, peer reviewed, open access journal focusing on blood and lymphatic cancer research, identification of therapeutic targets, and the optimal use of preventative and integrated treatment interventions to achieve improved outcomes, enhanced survival, and quality of life for the cancer patient. Specific topics covered in the journal include: Epidemiology, detection and screening Cellular research and biomarkers Identification of biotargets and agents with novel mechanisms of action Optimal clinical use of existing anticancer agents, including combination therapies Radiation, surgery, bone marrow transplantation Palliative care Patient adherence, quality of life, satisfaction Health economic evaluations.
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