[应用动脉自旋标记法研究早产儿脑灌注与脑白质损伤的关系]。

Q3 Medicine

中国当代儿科杂志 Pub Date : 2025-06-15 DOI:10.7499/j.issn.1008-8830.2501047

Xiang-Bo Kong, Fan-Yue Qin, Wen-Li Duan, Lin Lu, Xiao-Chan Guo, Yan-Ran Xue, Yin-Gang Hong, Fa-Lin Xu

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引用次数: 0

摘要

目的：应用动脉自旋标记法（ASL）探讨早产儿脑灌注与脑白质损伤（WMI）的关系。方法：共293例早产儿（胎龄66例）和非wmi组（227例）。比较各组间脑灌注参数，评价WMI与灌注改变的相关性。结果：WMI组轻度脑室内出血（IVH）发生率高于非WMI组（ppp）结论：早产儿WMI与局限性脑灌注不足有关。asl检测的灌注异常可能为WMI的发病机制提供新的见解。

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[Investigating the correlation between white matter injury and cerebral perfusion in preterm infants using arterial spin labeling].

Objectives: To explore the relationship between white matter injury (WMI) and cerebral perfusion in preterm infants using arterial spin labeling (ASL).

Methods: A total of 293 preterm infants (gestational age <34 weeks) hospitalized at the Third Affiliated Hospital of Zhengzhou University between June 2022 and June 2024 were included. After achieving clinical stability, the infants underwent brain magnetic resonance imaging (MRI) and ASL. Based on MRI findings, infants were classified into WMI (n=66) and non-WMI (n=227) groups. Cerebral perfusion parameters were compared between groups, and the association between WMI and perfusion alterations was evaluated.

Results: The WMI group showed a higher incidence of mild intraventricular hemorrhage (IVH) than the non-WMI group (P<0.05). Significantly lower cerebral perfusion was observed in the WMI group across bilateral frontal, temporal, parietal, and occipital lobes, as well as the basal ganglia and thalamus (P<0.05). After adjusting for gestational age, corrected gestational age at ASL scan, and mild IVH, WMI remained significantly associated with reduced regional perfusion (P<0.05).

Conclusions: WMI in preterm infants correlates with localized cerebral hypoperfusion. ASL-detected perfusion abnormalities may provide novel insights into WMI pathogenesis.

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来源期刊

中国当代儿科杂志 Medicine-Pediatrics, Perinatology and Child Health

CiteScore

1.50

自引率

0.00%

发文量

5006

期刊介绍： The Chinese Journal of Contemporary Pediatrics (CJCP) is a peer-reviewed open access periodical in the field of pediatrics that is sponsored by the Central South University/Xiangya Hospital of Central South University and under the auspices of the Ministry of Education of China. It is cited as a source in the scientific and technological papers of Chinese journals, the Chinese Science Citation Database (CSCD), and is one of the core Chinese periodicals in the Peking University Library. CJCP has been indexed by MEDLINE/PubMed/PMC of the American National Library, American Chemical Abstracts (CA), Holland Medical Abstracts (EM), Western Pacific Region Index Medicus (WPRIM), Scopus and EBSCO. It is a monthly periodical published on the 15th of every month, and is distributed both at home and overseas. The Chinese series publication number is CN 43-1301/R；ISSN 1008-8830. The tenet of CJCP is to “reflect the latest advances and be open to the world”. The periodical reports the most recent advances in the contemporary pediatric field. The majority of the readership is pediatric doctors and researchers.