[克罗恩病患儿不同诱导治疗前后营养状况分析]。

Q3 Medicine

中国当代儿科杂志 Pub Date : 2025-06-15 DOI:10.7499/j.issn.1008-8830.2410125

Lei-Lei Chen, Yu Yu, You-You Luo, Jie Chen

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引用次数: 0

摘要

目的：探讨不同诱导缓解疗法对克罗恩病（CD）患儿营养状况的影响。方法：回顾性分析2013年1月至2023年5月浙江大学医学院附属儿童医院接受诱导缓解治疗的188例CD患儿的医疗资料。比较了三种诱导缓解疗法——纯肠内营养（EEN）、皮质类固醇和英夫利昔单抗（IFX）对身高、体重、血红蛋白和微量元素的影响。结果：诱导缓解治疗后，三组患者体重年龄比Z评分及血清血红蛋白、白蛋白水平均显著升高（p < 0.05）。叶酸的水平,25-hydroxy维生素D,血清铁、总钙增加,血清铜水平下降甚至和IFX组(P12水平改善甚至集团(PConclusions:甚至,糖皮质激素,IFX可以有效改善体重Z分数和儿童的血清水平的血红蛋白和白蛋白和CD。即使IFX似乎优于皮质类固醇疗法在改善25-hydroxy维生素D,叶酸,血清铁、总钙含量。

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[Analysis of nutritional status before and after different induction therapies in children with Crohn's disease].

Objectives: To study the impact of different induction remission therapies on the nutritional status of children with Crohn's disease (CD).

Methods: A retrospective analysis was conducted on the medical data of 188 children with CD who received induction remission therapy at the Children's Hospital, Zhejiang University School of Medicine from January 2013 to May 2023. The effects of three induction remission therapies-exclusive enteral nutrition (EEN), corticosteroids, and infliximab (IFX)-on height, weight, hemoglobin, and trace elements were compared.

Results: After induction remission therapy, the weight-for-age Z scores and serum levels of hemoglobin and albumin in all three groups significantly increased (P<0.05), while the height-for-age Z scores showed no change (P>0.05). The levels of folic acid, 25-hydroxy vitamin D, serum iron, and total calcium increased, and serum copper levels decreased in the EEN and IFX groups (P<0.05). Vitamin B₁₂ levels improved in the EEN group (P<0.05).

Conclusions: EEN, corticosteroids, and IFX may effectively improve the weight-for-age Z scores and serum levels of hemoglobin and albumin in children with CD. EEN and IFX seem to be superior to corticosteroid therapy in improving 25-hydroxy vitamin D, folic acid, serum iron, and total calcium levels.

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来源期刊

中国当代儿科杂志 Medicine-Pediatrics, Perinatology and Child Health

CiteScore

1.50

自引率

0.00%

发文量

5006

期刊介绍： The Chinese Journal of Contemporary Pediatrics (CJCP) is a peer-reviewed open access periodical in the field of pediatrics that is sponsored by the Central South University/Xiangya Hospital of Central South University and under the auspices of the Ministry of Education of China. It is cited as a source in the scientific and technological papers of Chinese journals, the Chinese Science Citation Database (CSCD), and is one of the core Chinese periodicals in the Peking University Library. CJCP has been indexed by MEDLINE/PubMed/PMC of the American National Library, American Chemical Abstracts (CA), Holland Medical Abstracts (EM), Western Pacific Region Index Medicus (WPRIM), Scopus and EBSCO. It is a monthly periodical published on the 15th of every month, and is distributed both at home and overseas. The Chinese series publication number is CN 43-1301/R；ISSN 1008-8830. The tenet of CJCP is to “reflect the latest advances and be open to the world”. The periodical reports the most recent advances in the contemporary pediatric field. The majority of the readership is pediatric doctors and researchers.