Ayrton I Bangolo, Khaled Sharaan, Behzad Amoozgar, Shruti Wadhwani, Lili Zhang, Nikita Wadhwani, Vignesh K Nagesh, Jay Mehta, Rishabh Goyal, Gia DeRose, Sarvarinder Gill, Courtney Christoforo, Swapnika Mallipeddi, Selbin Boban, Shubham Madan, Budoor Alqinai, Timophyll Yh Fong, Simcha Weissman, Pierre Fwelo
{"title":"胃粘膜相关淋巴组织淋巴瘤的生存预测因素：年龄和性别差异的最新监测、流行病学和最终结果分析","authors":"Ayrton I Bangolo, Khaled Sharaan, Behzad Amoozgar, Shruti Wadhwani, Lili Zhang, Nikita Wadhwani, Vignesh K Nagesh, Jay Mehta, Rishabh Goyal, Gia DeRose, Sarvarinder Gill, Courtney Christoforo, Swapnika Mallipeddi, Selbin Boban, Shubham Madan, Budoor Alqinai, Timophyll Yh Fong, Simcha Weissman, Pierre Fwelo","doi":"10.5306/wjco.v16.i6.106408","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Mucosa-associated lymphoid tissue (MALT) lymphoma is a subtype of extranodal marginal zone lymphoma, typically occurring in mucosal sites such as the stomach, salivary glands, and lungs. This study aims to analyze the demographic and clinicopathologic characteristics of patients with gastric MALT lymphoma in the United States and evaluate the interaction between age and gender on survival outcomes.</p><p><strong>Aim: </strong>To analyze the demographic and clinicopathologic characteristics of patients with gastric MALT lymphoma in the United States and evaluate the interaction between age and gender on survival outcomes.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted using the Surveillance, Epidemiology, and End Results (SEER) database, which included 2453 patients diagnosed with MALT lymphoma from 2010 to 2021. Data were analyzed for demographic factors, tumor characteristics, treatment modalities, and survival outcomes. A Cox proportional hazards regression model was used to identify predictors of overall mortality and cancer-specific mortality.</p><p><strong>Results: </strong>The study predominantly included Non-Hispanic White patients (62.78%), with nearly equal gender distribution (50.31% females, 49.69% males), and most diagnoses occurring in individuals aged 60-79 years. The majority of tumors were localized (80.07%). Multivariate analysis identified older age, male gender, advanced tumor stage, and socioeconomic factors-such as annual income and marital status-as independent predictors of mortality. No significant interaction between age and gender on mortality outcomes was observed.</p><p><strong>Conclusion: </strong>Sociodemographic factors, including advanced age, male gender, annual income, and marital status, as well as advanced tumor stage, significantly impacted survival outcomes in patients with MALT lymphoma. Radiotherapy was associated with a reduction in overall mortality. Early detection is crucial for optimizing outcomes, as localized disease responds well to available treatment modalities.</p>","PeriodicalId":23802,"journal":{"name":"World journal of clinical oncology","volume":"16 6","pages":"106408"},"PeriodicalIF":3.2000,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198866/pdf/","citationCount":"0","resultStr":"{\"title\":\"Predictors of survival in gastric mucosa-associated lymphoid tissue lymphoma: An updated surveillance, epidemiology, and end results-based analysis of age and gender disparities.\",\"authors\":\"Ayrton I Bangolo, Khaled Sharaan, Behzad Amoozgar, Shruti Wadhwani, Lili Zhang, Nikita Wadhwani, Vignesh K Nagesh, Jay Mehta, Rishabh Goyal, Gia DeRose, Sarvarinder Gill, Courtney Christoforo, Swapnika Mallipeddi, Selbin Boban, Shubham Madan, Budoor Alqinai, Timophyll Yh Fong, Simcha Weissman, Pierre Fwelo\",\"doi\":\"10.5306/wjco.v16.i6.106408\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Mucosa-associated lymphoid tissue (MALT) lymphoma is a subtype of extranodal marginal zone lymphoma, typically occurring in mucosal sites such as the stomach, salivary glands, and lungs. This study aims to analyze the demographic and clinicopathologic characteristics of patients with gastric MALT lymphoma in the United States and evaluate the interaction between age and gender on survival outcomes.</p><p><strong>Aim: </strong>To analyze the demographic and clinicopathologic characteristics of patients with gastric MALT lymphoma in the United States and evaluate the interaction between age and gender on survival outcomes.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted using the Surveillance, Epidemiology, and End Results (SEER) database, which included 2453 patients diagnosed with MALT lymphoma from 2010 to 2021. Data were analyzed for demographic factors, tumor characteristics, treatment modalities, and survival outcomes. A Cox proportional hazards regression model was used to identify predictors of overall mortality and cancer-specific mortality.</p><p><strong>Results: </strong>The study predominantly included Non-Hispanic White patients (62.78%), with nearly equal gender distribution (50.31% females, 49.69% males), and most diagnoses occurring in individuals aged 60-79 years. The majority of tumors were localized (80.07%). Multivariate analysis identified older age, male gender, advanced tumor stage, and socioeconomic factors-such as annual income and marital status-as independent predictors of mortality. No significant interaction between age and gender on mortality outcomes was observed.</p><p><strong>Conclusion: </strong>Sociodemographic factors, including advanced age, male gender, annual income, and marital status, as well as advanced tumor stage, significantly impacted survival outcomes in patients with MALT lymphoma. Radiotherapy was associated with a reduction in overall mortality. Early detection is crucial for optimizing outcomes, as localized disease responds well to available treatment modalities.</p>\",\"PeriodicalId\":23802,\"journal\":{\"name\":\"World journal of clinical oncology\",\"volume\":\"16 6\",\"pages\":\"106408\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-06-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198866/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World journal of clinical oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5306/wjco.v16.i6.106408\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World journal of clinical oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5306/wjco.v16.i6.106408","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
Predictors of survival in gastric mucosa-associated lymphoid tissue lymphoma: An updated surveillance, epidemiology, and end results-based analysis of age and gender disparities.
Background: Mucosa-associated lymphoid tissue (MALT) lymphoma is a subtype of extranodal marginal zone lymphoma, typically occurring in mucosal sites such as the stomach, salivary glands, and lungs. This study aims to analyze the demographic and clinicopathologic characteristics of patients with gastric MALT lymphoma in the United States and evaluate the interaction between age and gender on survival outcomes.
Aim: To analyze the demographic and clinicopathologic characteristics of patients with gastric MALT lymphoma in the United States and evaluate the interaction between age and gender on survival outcomes.
Methods: A retrospective cohort study was conducted using the Surveillance, Epidemiology, and End Results (SEER) database, which included 2453 patients diagnosed with MALT lymphoma from 2010 to 2021. Data were analyzed for demographic factors, tumor characteristics, treatment modalities, and survival outcomes. A Cox proportional hazards regression model was used to identify predictors of overall mortality and cancer-specific mortality.
Results: The study predominantly included Non-Hispanic White patients (62.78%), with nearly equal gender distribution (50.31% females, 49.69% males), and most diagnoses occurring in individuals aged 60-79 years. The majority of tumors were localized (80.07%). Multivariate analysis identified older age, male gender, advanced tumor stage, and socioeconomic factors-such as annual income and marital status-as independent predictors of mortality. No significant interaction between age and gender on mortality outcomes was observed.
Conclusion: Sociodemographic factors, including advanced age, male gender, annual income, and marital status, as well as advanced tumor stage, significantly impacted survival outcomes in patients with MALT lymphoma. Radiotherapy was associated with a reduction in overall mortality. Early detection is crucial for optimizing outcomes, as localized disease responds well to available treatment modalities.
期刊介绍：
The WJCO is a high-quality, peer reviewed, open-access journal. The primary task of WJCO is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of oncology. In order to promote productive academic communication, the peer review process for the WJCO is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCO are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in oncology. Scope: Art of Oncology, Biology of Neoplasia, Breast Cancer, Cancer Prevention and Control, Cancer-Related Complications, Diagnosis in Oncology, Gastrointestinal Cancer, Genetic Testing For Cancer, Gynecologic Cancer, Head and Neck Cancer, Hematologic Malignancy, Lung Cancer, Melanoma, Molecular Oncology, Neurooncology, Palliative and Supportive Care, Pediatric Oncology, Surgical Oncology, Translational Oncology, and Urologic Oncology.
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