禽致病性大肠杆菌攻毒肉鸡中副干酪乳杆菌替代抗生素生长促进剂的效力

IF 2 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Veterinary World Pub Date : 2025-05-01 Epub Date: 2025-05-17 DOI:10.14202/vetworld.2025.1180-1189
Widya Paramita Lokapirnasari, Lilik Maslachah, Amung Logam Saputro, Efi Rokana, Andreas Berny Yulianto, Zulfi Nur Amrina Rosyada, Muhammad Aviv Firdaus, Himatul Ilma Silfia, Ertika Fitri Lisnanti, Zein Ahmad Baihaqi, Tabita Dameria Marbun, Aswin Rafif Khairullah, Muhammad Shakeel
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引用次数: 0

摘要

背景与目的:由于抗生素生长促进剂(AGPs)的广泛使用,抗生素耐药菌的出现要求在家禽生产中探索可持续的替代品。本研究对禽致病性大肠杆菌(APEC)感染肉鸡的生长性能、抗氧化状态、脂质代谢和血液学特征进行了研究,评估了副干酪乳杆菌作为AGPs益生菌替代品的效果。材料与方法:选用80只肉鸡,随机分为4组:T0组(未感染对照组)、T1组(APEC感染对照组)、T2组(APEC + AGP, 0.1%杆菌肽锌)和T3组(APEC +益生菌,0.5%副干酪乳杆菌)。预试期为2周,于孵化后第15 ~ 35天进行处理。评估生产性能指标(饲料系数[FCR]、体重增加[BWG]和饲料效率[FE])、抗氧化参数(超氧化物歧化酶[SOD]和丙二醛[MDA])、脂质谱(胆固醇、高密度脂蛋白和低密度脂蛋白)和血液学指标。数据采用方差分析,显著性设置为p < 0.05。结果:饲粮中添加益生菌可显著提高饲料增重比、体重增重和饲料效率(p < 0.05),其中T3组效果最佳。与AGP和感染组相比,益生菌处理的鸟类SOD活性明显升高,MDA水平降低。此外,副干酪乳杆菌可显著降低总胆固醇和低密度脂蛋白水平,同时保持适度的高密度脂蛋白浓度。血红蛋白和血小板水平受到轻微影响,但各组的整体血液学特征保持稳定。结论:添加副干酪乳杆菌可显著提高APEC应激肉鸡的生长性能、抗氧化防御和脂质代谢,支持其作为agp替代品的可行性。这些发现通过减少对抗生素的依赖,有助于可持续家禽生产实践和公共卫生安全。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Potency of Lacticaseibacillus paracasei as an alternative to antibiotic growth promoter in broiler chicken challenged with avian pathogenic Escherichia coli.

Background and aim: The emergence of antibiotic-resistant bacteria due to the widespread use of antibiotic growth promoters (AGPs) necessitates the exploration of sustainable alternatives in poultry production. This study evaluated the efficacy of Lacticaseibacillus paracasei as a probiotic alternative to AGPs in broilers challenged with avian pathogenic Escherichia coli (APEC), with a focus on growth performance, antioxidant status, lipid metabolism, and hematological profiles.

Materials and methods: A total of 80 broiler chickens were randomly allocated into four groups: T0 (uninfected control), T1 (APEC-infected control), T2 (APEC + AGP, 0.1% zinc bacitracin), and T3 (APEC + probiotic, 0.5% L. paracasei). Treatments were administered from day 15 to 35 post-hatch, following a 2-week adaptation period. Performance indicators (feed conversion ratio [FCR], body weight gain [BWG], and feed efficiency [FE]), antioxidant parameters (superoxide dismutase [SOD] and malondialdehyde [MDA]), lipid profiles (cholesterol, HDL, and LDL), and hematological variables were assessed. Data were analyzed using analysis of variance with significance set at p < 0.05.

Results: Probiotic supplementation significantly improved FCR, BWG, and FE (p < 0.05), with the T3 group achieving the most favorable outcomes. SOD activity was markedly higher, and MDA levels were reduced in probiotic-treated birds compared with the AGP and infected groups. Moreover, L. paracasei administration resulted in significant reductions in total cholesterol and LDL levels while maintaining moderate HDL concentrations. Hemoglobin and thrombocyte levels were modestly influenced, though overall hematological profiles remained stable across groups.

Conclusion: L. paracasei supplementation significantly enhanced growth performance, antioxidant defense, and lipid metabolism in broilers challenged with APEC, supporting its application as a viable alternative to AGPs. These findings contribute to sustainable poultry production practices and public health safety by mitigating the reliance on antibiotics.

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来源期刊
Veterinary World
Veterinary World Multiple-
CiteScore
3.60
自引率
12.50%
发文量
317
审稿时长
16 weeks
期刊介绍: Veterinary World publishes high quality papers focusing on Veterinary and Animal Science. The fields of study are bacteriology, parasitology, pathology, virology, immunology, mycology, public health, biotechnology, meat science, fish diseases, nutrition, gynecology, genetics, wildlife, laboratory animals, animal models of human infections, prion diseases and epidemiology. Studies on zoonotic and emerging infections are highly appreciated. Review articles are highly appreciated. All articles published by Veterinary World are made freely and permanently accessible online. All articles to Veterinary World are posted online immediately as they are ready for publication.
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