{"title":"在蝙蝠中产生esbl的大肠杆菌的生态和公共卫生方面:一个健康的观点。","authors":"Alfiana Laili Dwi Agustin, Aswin Rafif Khairullah, Mustofa Helmi Effendi, Wiwiek Tyasningsih, Ikechukwu Benjamin Moses, Budiastuti Budiastuti, Hani Plumeriastuti, Sheila Marty Yanestria, Katty Hendriana Priscilia Riwu, Fidi Nur Aini Eka Puji Dameanti, Wasito Wasito, Riza Zainuddin Ahmad, Agus Widodo, Daniah Ashri Afnani","doi":"10.14202/vetworld.2025.1199-1213","DOIUrl":null,"url":null,"abstract":"<p><p>The emergence and global dissemination of extended-spectrum β-lactamase (ESBL)-producing <i>Escherichia coli</i> represent a major public health concern. While antibiotic resistance in clinical and agricultural settings is well documented, the contribution of wildlife, particularly bats, to the spread of antimicrobial resistance (AMR) remains underexplored. Bats possess unique ecological traits - such as long-distance flight, longevity, and adaptability - that facilitate their role as potential reservoirs and vectors of antibiotic-resistant bacteria. This review synthesizes global findings on the occurrence, genetic characteristics, and transmission dynamics of ESBL-producing <i>E. coli</i> isolated from bats. Through a comprehensive literature review of studies conducted across five continents, we highlight the prevalence of multidrug-resistant <i>E. coli</i> in bat populations, with resistance profiles frequently including β-lactams (<i>bla</i>), aminoglycosides, tetracyclines, and fluoroquinolones. Notably, key ESBL genes such as <i>bla</i>CTX-M, <i>bla</i>TEM, <i>bla</i>SHV, and <i>bla</i>OXA have been identified in isolates from bat feces (guano), raising significant concern due to potential environmental contamination and zoonotic spillover. Risk factors such as habitat encroachment, anthropogenic waste exposure, and the agricultural use of bat guano further exacerbate the risk of ESBL transmission. Moreover, genomic comparisons suggest phylogenetic overlap between ESBL-producing <i>E. coli</i> from bats and those found in humans and livestock. Given these findings, bats warrant greater inclusion in One Health surveillance frameworks to trace AMR gene flow and develop targeted interventions. This review underscores the need for integrated AMR monitoring in wildlife, enhanced waste management policies, and stricter biosecurity to mitigate the public health risks associated with wildlife-origin ESBL dissemination.</p>","PeriodicalId":23587,"journal":{"name":"Veterinary World","volume":"18 5","pages":"1199-1213"},"PeriodicalIF":2.0000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205247/pdf/","citationCount":"0","resultStr":"{\"title\":\"Ecological and public health dimensions of ESBL-producing <i>Escherichia coli</i> in bats: A One Health perspective.\",\"authors\":\"Alfiana Laili Dwi Agustin, Aswin Rafif Khairullah, Mustofa Helmi Effendi, Wiwiek Tyasningsih, Ikechukwu Benjamin Moses, Budiastuti Budiastuti, Hani Plumeriastuti, Sheila Marty Yanestria, Katty Hendriana Priscilia Riwu, Fidi Nur Aini Eka Puji Dameanti, Wasito Wasito, Riza Zainuddin Ahmad, Agus Widodo, Daniah Ashri Afnani\",\"doi\":\"10.14202/vetworld.2025.1199-1213\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The emergence and global dissemination of extended-spectrum β-lactamase (ESBL)-producing <i>Escherichia coli</i> represent a major public health concern. While antibiotic resistance in clinical and agricultural settings is well documented, the contribution of wildlife, particularly bats, to the spread of antimicrobial resistance (AMR) remains underexplored. Bats possess unique ecological traits - such as long-distance flight, longevity, and adaptability - that facilitate their role as potential reservoirs and vectors of antibiotic-resistant bacteria. This review synthesizes global findings on the occurrence, genetic characteristics, and transmission dynamics of ESBL-producing <i>E. coli</i> isolated from bats. Through a comprehensive literature review of studies conducted across five continents, we highlight the prevalence of multidrug-resistant <i>E. coli</i> in bat populations, with resistance profiles frequently including β-lactams (<i>bla</i>), aminoglycosides, tetracyclines, and fluoroquinolones. Notably, key ESBL genes such as <i>bla</i>CTX-M, <i>bla</i>TEM, <i>bla</i>SHV, and <i>bla</i>OXA have been identified in isolates from bat feces (guano), raising significant concern due to potential environmental contamination and zoonotic spillover. Risk factors such as habitat encroachment, anthropogenic waste exposure, and the agricultural use of bat guano further exacerbate the risk of ESBL transmission. Moreover, genomic comparisons suggest phylogenetic overlap between ESBL-producing <i>E. coli</i> from bats and those found in humans and livestock. Given these findings, bats warrant greater inclusion in One Health surveillance frameworks to trace AMR gene flow and develop targeted interventions. This review underscores the need for integrated AMR monitoring in wildlife, enhanced waste management policies, and stricter biosecurity to mitigate the public health risks associated with wildlife-origin ESBL dissemination.</p>\",\"PeriodicalId\":23587,\"journal\":{\"name\":\"Veterinary World\",\"volume\":\"18 5\",\"pages\":\"1199-1213\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205247/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Veterinary World\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14202/vetworld.2025.1199-1213\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/5/17 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"AGRICULTURE, DAIRY & ANIMAL SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary World","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14202/vetworld.2025.1199-1213","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/17 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"AGRICULTURE, DAIRY & ANIMAL SCIENCE","Score":null,"Total":0}
Ecological and public health dimensions of ESBL-producing Escherichia coli in bats: A One Health perspective.
The emergence and global dissemination of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli represent a major public health concern. While antibiotic resistance in clinical and agricultural settings is well documented, the contribution of wildlife, particularly bats, to the spread of antimicrobial resistance (AMR) remains underexplored. Bats possess unique ecological traits - such as long-distance flight, longevity, and adaptability - that facilitate their role as potential reservoirs and vectors of antibiotic-resistant bacteria. This review synthesizes global findings on the occurrence, genetic characteristics, and transmission dynamics of ESBL-producing E. coli isolated from bats. Through a comprehensive literature review of studies conducted across five continents, we highlight the prevalence of multidrug-resistant E. coli in bat populations, with resistance profiles frequently including β-lactams (bla), aminoglycosides, tetracyclines, and fluoroquinolones. Notably, key ESBL genes such as blaCTX-M, blaTEM, blaSHV, and blaOXA have been identified in isolates from bat feces (guano), raising significant concern due to potential environmental contamination and zoonotic spillover. Risk factors such as habitat encroachment, anthropogenic waste exposure, and the agricultural use of bat guano further exacerbate the risk of ESBL transmission. Moreover, genomic comparisons suggest phylogenetic overlap between ESBL-producing E. coli from bats and those found in humans and livestock. Given these findings, bats warrant greater inclusion in One Health surveillance frameworks to trace AMR gene flow and develop targeted interventions. This review underscores the need for integrated AMR monitoring in wildlife, enhanced waste management policies, and stricter biosecurity to mitigate the public health risks associated with wildlife-origin ESBL dissemination.
期刊介绍:
Veterinary World publishes high quality papers focusing on Veterinary and Animal Science. The fields of study are bacteriology, parasitology, pathology, virology, immunology, mycology, public health, biotechnology, meat science, fish diseases, nutrition, gynecology, genetics, wildlife, laboratory animals, animal models of human infections, prion diseases and epidemiology. Studies on zoonotic and emerging infections are highly appreciated. Review articles are highly appreciated. All articles published by Veterinary World are made freely and permanently accessible online. All articles to Veterinary World are posted online immediately as they are ready for publication.