在蝙蝠中产生esbl的大肠杆菌的生态和公共卫生方面:一个健康的观点。

IF 2 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Veterinary World Pub Date : 2025-05-01 Epub Date: 2025-05-17 DOI:10.14202/vetworld.2025.1199-1213
Alfiana Laili Dwi Agustin, Aswin Rafif Khairullah, Mustofa Helmi Effendi, Wiwiek Tyasningsih, Ikechukwu Benjamin Moses, Budiastuti Budiastuti, Hani Plumeriastuti, Sheila Marty Yanestria, Katty Hendriana Priscilia Riwu, Fidi Nur Aini Eka Puji Dameanti, Wasito Wasito, Riza Zainuddin Ahmad, Agus Widodo, Daniah Ashri Afnani
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引用次数: 0

摘要

产生广谱β-内酰胺酶(ESBL)的大肠杆菌的出现和全球传播是一个重大的公共卫生问题。虽然临床和农业环境中的抗生素耐药性有充分的记录,但野生动物,特别是蝙蝠,对抗菌素耐药性(AMR)传播的贡献仍未得到充分探讨。蝙蝠具有独特的生态特征,如长距离飞行、长寿和适应性,这有助于它们成为耐抗生素细菌的潜在宿主和载体。本文综述了从蝙蝠分离的产esbl大肠杆菌的发生、遗传特征和传播动力学方面的全球发现。通过对五大洲研究的综合文献回顾,我们强调了多重耐药大肠杆菌在蝙蝠种群中的流行,其耐药谱通常包括β-内酰胺类(bla)、氨基糖苷类、四环素类和氟喹诺酮类药物。值得注意的是,在蝙蝠粪便(鸟粪)分离物中发现了关键的ESBL基因,如blaCTX-M、blaTEM、blaSHV和blaOXA,这引起了人们对潜在环境污染和人畜共患外溢的严重关注。生境侵占、人为废弃物暴露和农业使用蝙蝠粪便等风险因素进一步加剧了ESBL传播的风险。此外,基因组比较表明,来自蝙蝠的产生esbl的大肠杆菌与在人类和牲畜中发现的大肠杆菌之间的系统发育重叠。鉴于这些发现,蝙蝠有必要更多地纳入One Health监测框架,以追踪抗菌素耐药性基因流并制定有针对性的干预措施。这一综述强调了在野生动物中进行抗菌素耐药性综合监测、加强废物管理政策和更严格的生物安全的必要性,以减轻与野生动物来源的ESBL传播相关的公共卫生风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ecological and public health dimensions of ESBL-producing Escherichia coli in bats: A One Health perspective.

The emergence and global dissemination of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli represent a major public health concern. While antibiotic resistance in clinical and agricultural settings is well documented, the contribution of wildlife, particularly bats, to the spread of antimicrobial resistance (AMR) remains underexplored. Bats possess unique ecological traits - such as long-distance flight, longevity, and adaptability - that facilitate their role as potential reservoirs and vectors of antibiotic-resistant bacteria. This review synthesizes global findings on the occurrence, genetic characteristics, and transmission dynamics of ESBL-producing E. coli isolated from bats. Through a comprehensive literature review of studies conducted across five continents, we highlight the prevalence of multidrug-resistant E. coli in bat populations, with resistance profiles frequently including β-lactams (bla), aminoglycosides, tetracyclines, and fluoroquinolones. Notably, key ESBL genes such as blaCTX-M, blaTEM, blaSHV, and blaOXA have been identified in isolates from bat feces (guano), raising significant concern due to potential environmental contamination and zoonotic spillover. Risk factors such as habitat encroachment, anthropogenic waste exposure, and the agricultural use of bat guano further exacerbate the risk of ESBL transmission. Moreover, genomic comparisons suggest phylogenetic overlap between ESBL-producing E. coli from bats and those found in humans and livestock. Given these findings, bats warrant greater inclusion in One Health surveillance frameworks to trace AMR gene flow and develop targeted interventions. This review underscores the need for integrated AMR monitoring in wildlife, enhanced waste management policies, and stricter biosecurity to mitigate the public health risks associated with wildlife-origin ESBL dissemination.

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来源期刊
Veterinary World
Veterinary World Multiple-
CiteScore
3.60
自引率
12.50%
发文量
317
审稿时长
16 weeks
期刊介绍: Veterinary World publishes high quality papers focusing on Veterinary and Animal Science. The fields of study are bacteriology, parasitology, pathology, virology, immunology, mycology, public health, biotechnology, meat science, fish diseases, nutrition, gynecology, genetics, wildlife, laboratory animals, animal models of human infections, prion diseases and epidemiology. Studies on zoonotic and emerging infections are highly appreciated. Review articles are highly appreciated. All articles published by Veterinary World are made freely and permanently accessible online. All articles to Veterinary World are posted online immediately as they are ready for publication.
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