{"title":"胃癌T3-T4分期的临床特征及经腹超声特征的回顾性研究","authors":"Min-Ying Zhong, Guo-Liang Jian, Jie-Yi Ye, Qin-Xue Liu, Wei-Jun Huang, Chao-Jiong Zhen","doi":"10.4240/wjgs.v17.i6.105073","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Transabdominal ultrasound after the oral administration of an echoic cellulose-based gastric ultrasound contrast agent has recently been suggested to be effective in T staging of gastric cancer (GC).</p><p><strong>Aim: </strong>To explore the clinical characteristics and transabdominal features associated with T3-T4 staging of GC.</p><p><strong>Methods: </strong>In total, 113 patients who underwent transabdominal ultrasonography and had confirmed GC based on surgical pathology were included. Variables including clinical characteristics [age, body mass index, gender, clinical features, pathological type, histologic type, Lauren type, carcinoembryonic antigen (CEA), and CA19-9] and transabdominal ultrasound features (thickness and length of lesion, presence of angle sign, presence of ulcer, and lesion location) were recorded. Univariate and multivariable logistic regression analyses were performed to identify the factors associated with T3-T4 staging.</p><p><strong>Results: </strong>Ninety-two patients were T3-T4 staging and 21 were T1-T2 staging. Univariate analysis revealed that the thickness of gastric lesions (1.6 ± 0.6 cm <i>vs</i> 1.0 ± 0.4 cm, <i>P</i> < 0.001), length of gastric lesions (5.7 ± 2.2 cm <i>vs</i> 2.9 ± 1.0 cm, <i>P</i> < 0.001), presence of angle sign (92.4% <i>vs</i> 19.0%, <i>P</i> < 0.001), elevated CEA (36.9% <i>vs</i> 0%, <i>P</i> < 0.001) and elevated CA19-9 (27.2% <i>vs</i> 14.3%, <i>P</i> = 0.034) were statistically significant between the two groups. Multivariable logistic regression analysis revealed that the length of gastric lesions [odds ratio (OR) = 2.373, 95% confidence interval (95%CI): 1.281-4.396, <i>P</i> = 0.006] and presence of angle sign (OR = 31.083, 95%CI: 4.449-217.164, <i>P</i> < 0.001) were independent factors associated with T3-T4 staging. A receiver operating characteristic curve was plotted, and the area under the curve was 0.950 (95% CI: 0.906-0.994, <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Transabdominal ultrasound features, including an angle sign and lesion length, help identify T3-T4 staging.</p>","PeriodicalId":23759,"journal":{"name":"World Journal of Gastrointestinal Surgery","volume":"17 6","pages":"105073"},"PeriodicalIF":1.8000,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188599/pdf/","citationCount":"0","resultStr":"{\"title\":\"Clinical characteristics and transabdominal ultrasound features that associated with T3-T4 staging in gastric cancer: A retrospective study.\",\"authors\":\"Min-Ying Zhong, Guo-Liang Jian, Jie-Yi Ye, Qin-Xue Liu, Wei-Jun Huang, Chao-Jiong Zhen\",\"doi\":\"10.4240/wjgs.v17.i6.105073\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Transabdominal ultrasound after the oral administration of an echoic cellulose-based gastric ultrasound contrast agent has recently been suggested to be effective in T staging of gastric cancer (GC).</p><p><strong>Aim: </strong>To explore the clinical characteristics and transabdominal features associated with T3-T4 staging of GC.</p><p><strong>Methods: </strong>In total, 113 patients who underwent transabdominal ultrasonography and had confirmed GC based on surgical pathology were included. Variables including clinical characteristics [age, body mass index, gender, clinical features, pathological type, histologic type, Lauren type, carcinoembryonic antigen (CEA), and CA19-9] and transabdominal ultrasound features (thickness and length of lesion, presence of angle sign, presence of ulcer, and lesion location) were recorded. Univariate and multivariable logistic regression analyses were performed to identify the factors associated with T3-T4 staging.</p><p><strong>Results: </strong>Ninety-two patients were T3-T4 staging and 21 were T1-T2 staging. Univariate analysis revealed that the thickness of gastric lesions (1.6 ± 0.6 cm <i>vs</i> 1.0 ± 0.4 cm, <i>P</i> < 0.001), length of gastric lesions (5.7 ± 2.2 cm <i>vs</i> 2.9 ± 1.0 cm, <i>P</i> < 0.001), presence of angle sign (92.4% <i>vs</i> 19.0%, <i>P</i> < 0.001), elevated CEA (36.9% <i>vs</i> 0%, <i>P</i> < 0.001) and elevated CA19-9 (27.2% <i>vs</i> 14.3%, <i>P</i> = 0.034) were statistically significant between the two groups. Multivariable logistic regression analysis revealed that the length of gastric lesions [odds ratio (OR) = 2.373, 95% confidence interval (95%CI): 1.281-4.396, <i>P</i> = 0.006] and presence of angle sign (OR = 31.083, 95%CI: 4.449-217.164, <i>P</i> < 0.001) were independent factors associated with T3-T4 staging. A receiver operating characteristic curve was plotted, and the area under the curve was 0.950 (95% CI: 0.906-0.994, <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Transabdominal ultrasound features, including an angle sign and lesion length, help identify T3-T4 staging.</p>\",\"PeriodicalId\":23759,\"journal\":{\"name\":\"World Journal of Gastrointestinal Surgery\",\"volume\":\"17 6\",\"pages\":\"105073\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-06-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188599/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World Journal of Gastrointestinal Surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4240/wjgs.v17.i6.105073\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of Gastrointestinal Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4240/wjgs.v17.i6.105073","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景：口服超声纤维素胃超声造影剂后的经腹超声最近被认为对胃癌（GC）的T分期有效。目的：探讨胃癌T3-T4分期的临床特点及经腹特征。方法：113例经腹部超声检查经手术病理证实为胃癌的患者。记录临床特征[年龄、体重指数、性别、临床特征、病理类型、组织学类型、Lauren类型、癌胚抗原（CEA）、CA19-9]和经腹超声特征（病变厚度、长度、有无角征、有无溃疡、病变部位）等变量。进行单因素和多因素logistic回归分析，以确定与T3-T4分期相关的因素。结果：T3-T4分期92例，T1-T2分期21例。单因素分析显示，两组患者胃病变厚度（1.6±0.6 cm vs 1.0±0.4 cm, P < 0.001）、胃病变长度（5.7±2.2 cm vs 2.9±1.0 cm, P < 0.001）、角征（92.4% vs 19.0%, P < 0.001）、CEA升高（36.9% vs 0%, P < 0.001）、CA19-9升高（27.2% vs 14.3%, P = 0.034）差异均有统计学意义。多变量logistic回归分析显示，胃病变长度[比值比(OR) = 2.373, 95%可信区间（95% ci）： 1.281 ~ 4.396, P = 0.006]和有无角征（OR = 31.083, 95% ci: 4.449 ~ 217.164, P < 0.001）是与T3-T4分期相关的独立因素。绘制受试者工作特征曲线，曲线下面积为0.950 （95% CI: 0.906 ~ 0.994, P < 0.001）。结论：经腹超声特征，包括角度征象和病变长度，有助于鉴别T3-T4分期。
Clinical characteristics and transabdominal ultrasound features that associated with T3-T4 staging in gastric cancer: A retrospective study.
Background: Transabdominal ultrasound after the oral administration of an echoic cellulose-based gastric ultrasound contrast agent has recently been suggested to be effective in T staging of gastric cancer (GC).
Aim: To explore the clinical characteristics and transabdominal features associated with T3-T4 staging of GC.
Methods: In total, 113 patients who underwent transabdominal ultrasonography and had confirmed GC based on surgical pathology were included. Variables including clinical characteristics [age, body mass index, gender, clinical features, pathological type, histologic type, Lauren type, carcinoembryonic antigen (CEA), and CA19-9] and transabdominal ultrasound features (thickness and length of lesion, presence of angle sign, presence of ulcer, and lesion location) were recorded. Univariate and multivariable logistic regression analyses were performed to identify the factors associated with T3-T4 staging.
Results: Ninety-two patients were T3-T4 staging and 21 were T1-T2 staging. Univariate analysis revealed that the thickness of gastric lesions (1.6 ± 0.6 cm vs 1.0 ± 0.4 cm, P < 0.001), length of gastric lesions (5.7 ± 2.2 cm vs 2.9 ± 1.0 cm, P < 0.001), presence of angle sign (92.4% vs 19.0%, P < 0.001), elevated CEA (36.9% vs 0%, P < 0.001) and elevated CA19-9 (27.2% vs 14.3%, P = 0.034) were statistically significant between the two groups. Multivariable logistic regression analysis revealed that the length of gastric lesions [odds ratio (OR) = 2.373, 95% confidence interval (95%CI): 1.281-4.396, P = 0.006] and presence of angle sign (OR = 31.083, 95%CI: 4.449-217.164, P < 0.001) were independent factors associated with T3-T4 staging. A receiver operating characteristic curve was plotted, and the area under the curve was 0.950 (95% CI: 0.906-0.994, P < 0.001).
Conclusion: Transabdominal ultrasound features, including an angle sign and lesion length, help identify T3-T4 staging.
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