诱导多能干细胞衍生的细胞模型研究帕金森病的发病机制和药物筛选。

IF 4.2 3区 医学 Q2 CELL & TISSUE ENGINEERING
Jihong Liu, Wanlin Zhao, Zijuan Zhang, Xilei Ai, Bing Cao, Zhenqiang Zhang, Dongrui Ma
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引用次数: 0

摘要

帕金森病(PD)是第二大最常见的神经退行性疾病,影响着全世界数百万人。PD的复杂性阻碍了准确疾病模型的发展。诱导多能干细胞(iPSCs)来源于患者特异性细胞,为帕金森病的建模提供了一个很有前景的平台。本文讨论了利用不同患者来源的iPSCs建立PD模型,重点是2D和3D培养系统。我们还探讨了iPSCs与多组学、组织工程和基因编辑等先进技术的整合,以及它们在疾病建模方面推动突破的潜力。ipsc衍生的神经元和胶质细胞的共培养系统提供了PD中细胞间相互作用的见解,而3D脑区域特异性类器官增强了对区域间疾病过程的理解。多组学和基因编辑的进步进一步推动了基于ipsc的疾病建模,为研究疾病机制和治疗筛选提供了新的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Induced Pluripotent Stem Cells Derived Cellular Models for Investigating Parkinson's Disease Pathogenesis and Drug Screening.

Parkinson's disease (PD) is the second most common neurodegenerative disorder, affecting millions worldwide. The complexity of PD has hindered the development of accurate disease models. Induced pluripotent stem cells (iPSCs), derived from patient-specific cells, offer a promising platform for modeling PD. This review discusses the development of PD models using iPSCs from different patient sources, focusing on 2D and 3D culture systems. We also explore the integration of iPSCs with advanced technologies like multi-omics, tissue engineering, and gene editing, and their potential to drive breakthroughs in disease modeling. Co-culture systems of iPSC-derived neurons and glial cells provide insights into cell-cell interactions in PD, while 3D brain region-specific organoids enhance understanding of interregional disease processes. Advances in multi-omics and gene editing have further propelled iPSC-based disease modeling, offering new avenues for investigating disease mechanisms and therapeutic screening.

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来源期刊
Stem Cell Reviews and Reports
Stem Cell Reviews and Reports 医学-细胞生物学
CiteScore
9.30
自引率
4.20%
发文量
0
审稿时长
3 months
期刊介绍: The purpose of Stem Cell Reviews and Reports is to cover contemporary and emerging areas in stem cell research and regenerative medicine. The journal will consider for publication: i) solicited or unsolicited reviews of topical areas of stem cell biology that highlight, critique and synthesize recent important findings in the field. ii) full length and short reports presenting original experimental work. iii) translational stem cell studies describing results of clinical trials using stem cells as therapeutics. iv) papers focused on diseases of stem cells. v) hypothesis and commentary articles as opinion-based pieces in which authors can propose a new theory, interpretation of a controversial area in stem cell biology, or a stem cell biology question or paradigm. These articles contain more speculation than reviews, but they should be based on solid rationale. vi) protocols as peer-reviewed procedures that provide step-by-step descriptions, outlined in sufficient detail, so that both experts and novices can apply them to their own research. vii) letters to the editor and correspondence. In order to facilitate this exchange of scientific information and exciting novel ideas, the journal has created five thematic sections, focusing on: i) the role of adult stem cells in tissue regeneration; ii) progress in research on induced pluripotent stem cells, embryonic stem cells and mechanism governing embryogenesis and tissue development; iii) the role of microenvironment and extracellular microvesicles in directing the fate of stem cells; iv) mechanisms of stem cell trafficking, stem cell mobilization and homing with special emphasis on hematopoiesis; v) the role of stem cells in aging processes and cancerogenesis.
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