{"title":"苦蒿中11个未描述的双abolane型倍半萜。","authors":"Jakhongir Umaraliev , Adkham Ganiev , Ablajan Turak , Nurmirza Begmatov , Khayrulla Bobakulov , Nasrulla Abdullaev , Zhao Jiangyu , Haji Akber Aisa","doi":"10.1016/j.phytochem.2025.114602","DOIUrl":null,"url":null,"abstract":"<div><div>Eleven previously undescribed bisabolane-type sesquiterpenoids were successfully isolated from <em>Artemisia persica</em>. The structures of these compounds were comprehensively elucidated through a combination of advanced spectroscopic techniques, including one-dimensional and two-dimensional nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, and ultraviolet spectroscopy. Structural assignments were further confirmed by comparison of experimental and time-dependent density functional theory-calculated electronic circular dichroism spectra, as well as single-crystal X-ray diffraction analysis where applicable. To assess their pharmacological relevance, the isolated sesquiterpenoids were subjected to <em>in vitro</em> evaluation of anti-inflammatory activity and cytotoxic potential. Compounds 6 and 9 demonstrated limited anti-inflammatory activity in the lipopolysaccharide-induced inflammation model using RAW 264.7 mouse macrophages, with IC<sub>50</sub> values of 111.1 ± 4.66 μM and 247.8 ± 1.49 μM, respectively.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"239 ","pages":"Article 114602"},"PeriodicalIF":3.4000,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Eleven undescribed bisabolane-type sesquiterpenoids from Artemisia persica\",\"authors\":\"Jakhongir Umaraliev , Adkham Ganiev , Ablajan Turak , Nurmirza Begmatov , Khayrulla Bobakulov , Nasrulla Abdullaev , Zhao Jiangyu , Haji Akber Aisa\",\"doi\":\"10.1016/j.phytochem.2025.114602\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Eleven previously undescribed bisabolane-type sesquiterpenoids were successfully isolated from <em>Artemisia persica</em>. The structures of these compounds were comprehensively elucidated through a combination of advanced spectroscopic techniques, including one-dimensional and two-dimensional nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, and ultraviolet spectroscopy. Structural assignments were further confirmed by comparison of experimental and time-dependent density functional theory-calculated electronic circular dichroism spectra, as well as single-crystal X-ray diffraction analysis where applicable. To assess their pharmacological relevance, the isolated sesquiterpenoids were subjected to <em>in vitro</em> evaluation of anti-inflammatory activity and cytotoxic potential. Compounds 6 and 9 demonstrated limited anti-inflammatory activity in the lipopolysaccharide-induced inflammation model using RAW 264.7 mouse macrophages, with IC<sub>50</sub> values of 111.1 ± 4.66 μM and 247.8 ± 1.49 μM, respectively.</div></div>\",\"PeriodicalId\":20170,\"journal\":{\"name\":\"Phytochemistry\",\"volume\":\"239 \",\"pages\":\"Article 114602\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-06-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0031942225002250\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031942225002250","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Eleven undescribed bisabolane-type sesquiterpenoids from Artemisia persica
Eleven previously undescribed bisabolane-type sesquiterpenoids were successfully isolated from Artemisia persica. The structures of these compounds were comprehensively elucidated through a combination of advanced spectroscopic techniques, including one-dimensional and two-dimensional nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, and ultraviolet spectroscopy. Structural assignments were further confirmed by comparison of experimental and time-dependent density functional theory-calculated electronic circular dichroism spectra, as well as single-crystal X-ray diffraction analysis where applicable. To assess their pharmacological relevance, the isolated sesquiterpenoids were subjected to in vitro evaluation of anti-inflammatory activity and cytotoxic potential. Compounds 6 and 9 demonstrated limited anti-inflammatory activity in the lipopolysaccharide-induced inflammation model using RAW 264.7 mouse macrophages, with IC50 values of 111.1 ± 4.66 μM and 247.8 ± 1.49 μM, respectively.
期刊介绍:
Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.