VEGF与MVD在I型子宫内膜癌中的表达及关系

IF 1.3 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Suning Bai, Qi Wu, Liyun Song
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引用次数: 0

摘要

背景:近年来,随着人们生活水平的提高,世界范围内子宫内膜癌的发病率呈上升趋势,年轻化趋势。早期子宫内膜癌患者手术治疗后预后良好,而晚期患者预后较差。因此,如果能够找到与子宫内膜癌发生发展相关的具有高敏感性和特异性的生物学指标,将为预测子宫内膜癌的预后和评价治疗效果提供临床参考。血管内皮生长因子(VEGF)是血管生成的正调节因子,微血管密度(MVD)是血管生成的定量指标。本研究通过研究VEGF和MVD在子宫内膜癌和正常子宫内膜组织中的表达,探讨其在子宫内膜癌形成发展中的作用。方法:采用免疫组化技术(SP法)检测38例子宫内膜癌和20例正常子宫内膜石蜡切片中VEGF和MVD的表达。采用SPSS 17.0统计软件进行统计学分析。结果:VEGF在子宫内膜癌组的阳性表达明显高于正常子宫内膜组。MVD在子宫内膜癌组的表达水平明显高于正常子宫内膜组。在子宫内膜癌中,VEGF表达与MVD呈正相关(R = 0.811, P)。结论:VEGF和MVD表达水平在子宫内膜癌中显著升高,且两者在子宫内膜癌中呈正相关。MVD与子宫内膜癌的手术病理分期、淋巴结转移、肌壁浸润深度有关,提示局部新生血管和丰富的血供在子宫内膜癌的发生发展中起着重要作用。VEGF与子宫内膜癌肌壁浸润深度有关,与手术病理分期及淋巴结转移无关。我们认为在子宫内膜癌手术病理分期和淋巴结转移过程中,除VEGF外,还有其他血管生成因子对血管生成起调节作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The expression and relationship of VEGF and MVD in type I endometrial cancer.

Background: In recent years, with the improvement of people's living standards, the incidence rate of endometrial cancer shows a rising and younger trend in the world. Early stage endometrial cancer patients have a good prognosis after surgical treatment, but late stage patients have a poor prognosis. Therefore, if biological indicators related to the occurrence and development of endometrial cancer with high sensitivity and specificity can be found, it will provide clinical reference for predicting the prognosis of endometrial cancer and evaluating treatment effectiveness. Vascular endothelial growth factor (VEGF) is a positive regulator of angiogenesis, while microvascular density (MVD) is a quantitative indicator of angiogenesis. This study investigates the expression of VEGF and MVD in endometrial cancer and normal endometrial tissue, and explores their roles in the formation and development of endometrial cancer.

Method: Immunohistochemical technique (SP method) was used to detect the expression of VEGF and MVD in paraffin sections of 38 cases of endometrial cancer and 20 cases of normal endometrium. Statistical analysis was conducted using statistical software SPSS 17.0.

Results: The positivity of VEGF in the endometrial cancer group was significantly higher than that in the normal endometrial group. The expression level of MVD in the endometrial cancer group was significantly higher than that in the normal endometrial group. In endometrial cancer, the expression of VEGF is positively correlated with MVD (R = 0.811, P < .001).

Conclusion: The expression levels of VEGF and MVD are significantly increased in endometrial cancer, and both are positively correlated in endometrial cancer. MVD is related to the surgical pathological staging, lymph node metastasis, and depth of muscle wall infiltration of endometrial cancer, indicating that local neovascularization and rich blood supply play an important role in the occurrence and development of endometrial cancer. VEGF is related to the depth of muscle wall infiltration in endometrial cancer, but not to surgical pathological staging and lymph node metastasis. It is considered that other angiogenic factors besides VEGF play a role in regulating angiogenesis during surgical pathological staging and lymph node metastasis of endometrial cancer.

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来源期刊
Medicine
Medicine 医学-医学:内科
CiteScore
2.80
自引率
0.00%
发文量
4342
审稿时长
>12 weeks
期刊介绍: Medicine is now a fully open access journal, providing authors with a distinctive new service offering continuous publication of original research across a broad spectrum of medical scientific disciplines and sub-specialties. As an open access title, Medicine will continue to provide authors with an established, trusted platform for the publication of their work. To ensure the ongoing quality of Medicine’s content, the peer-review process will only accept content that is scientifically, technically and ethically sound, and in compliance with standard reporting guidelines.
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