辅助生殖技术在多囊卵巢综合征合并空卵泡综合征患者中的成功效果:1例报告。

IF 1.4 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Danyang Guo, Lin Zhang, Xiaoxia Lin, Sha Tang, Bin Zhang, Linlin Ni
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引用次数: 0

摘要

理由:空卵泡综合征(EFS)是一种罕见且难以治疗的疾病。肥胖多囊卵巢综合征(PCOS)被认为是其独立的危险因素。在本研究中,我们报告一例肥胖多囊卵巢综合征合并EFS的成功妊娠,并讨论EFS的发病机制和最佳治疗策略。患者关注:一名25岁女性,“6年未避孕不孕”。诊断:原发性不孕症,双侧输卵管梗阻,多囊卵巢综合征和EFS。干预措施:患者接受2个周期的卵巢控制刺激。在第一个周期中,尽管卵巢有足够的刺激,但未获得卵母细胞,因此诊断为EFS。在第二个周期,我们采取了以下优化措施:使用贝因纳鲁肽帮助患者减肥和改善血糖水平,补充促黄体激素活性药物(如注射用促绝经激素),增加人绒毛膜促性腺激素剂量,在患者血糖水平稳定后,添加生长激素改善卵母细胞回收结果。结果:第二周期成功获得15个卵母细胞,其中13个卵母细胞处于中期II期,培养出5个高质量胚胎。患者冷冻胚胎移植后妊娠成功,随访至晚期妊娠,无异常。经验教训:多种复杂的机制可能参与了EFS的发展,预处理和个性化治疗方案对于改善EFS患者的预后至关重要。我们的治疗方案为EFS的治疗提供了一定的参考依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Successful outcome of assisted reproductive technology in women with polycystic ovary syndrome combined with empty follicle syndrome: A case report.

Rationale: Empty follicle syndrome (EFS) is a rare and difficult-to-treat condition. Obese polycystic ovary syndrome (PCOS) is considered an independent risk factor for it. In this study, we report a case of successful pregnancy in an obese patient with PCOS combined with EFS and discuss the pathogenesis of EFS and optimal treatment strategies.

Patient concerns: A 25-year-old woman presents with "6 years of infertility without contraception."

Diagnoses: Primary infertility, bilateral fallopian tube obstruction, PCOS, and EFS.

Interventions: The patient underwent 2 cycles of controlled ovarian stimulation. In the first cycle, despite adequate ovarian stimulation, oocytes were not obtained and a diagnosis of EFS was made. In the second cycle, the following optimization measures were taken: the use of beinaglutide to help the patient lose weight and improve her blood glucose levels, supplementation with luteinizing hormone-active medications (e.g., Menotropins for injection), an increase in the dose of human chorionic gonadotropin, and the addition of growth hormone to improve the outcome of oocytes retrieval once the patient's blood glucose levels had stabilized.

Outcomes: In the second cycle, 15 oocytes were successfully obtained, 13 oocytes of which were Metaphase II, resulting in the culture of 5 high-quality embryos. The patient had a successful pregnancy after frozen embryo transfer and was followed up to late-term pregnancy without abnormalities.

Lessons: Multiple complex mechanisms may be involved in the development of EFS, and preconditioning and individualized treatment protocols are essential for improving outcomes in patients with EFS. Our treatment protocol provides some reference basis for the treatment of EFS.

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来源期刊
Medicine
Medicine 医学-医学:内科
CiteScore
2.80
自引率
0.00%
发文量
4342
审稿时长
>12 weeks
期刊介绍: Medicine is now a fully open access journal, providing authors with a distinctive new service offering continuous publication of original research across a broad spectrum of medical scientific disciplines and sub-specialties. As an open access title, Medicine will continue to provide authors with an established, trusted platform for the publication of their work. To ensure the ongoing quality of Medicine’s content, the peer-review process will only accept content that is scientifically, technically and ethically sound, and in compliance with standard reporting guidelines.
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