Danyang Guo, Lin Zhang, Xiaoxia Lin, Sha Tang, Bin Zhang, Linlin Ni
{"title":"辅助生殖技术在多囊卵巢综合征合并空卵泡综合征患者中的成功效果:1例报告。","authors":"Danyang Guo, Lin Zhang, Xiaoxia Lin, Sha Tang, Bin Zhang, Linlin Ni","doi":"10.1097/MD.0000000000043001","DOIUrl":null,"url":null,"abstract":"<p><strong>Rationale: </strong>Empty follicle syndrome (EFS) is a rare and difficult-to-treat condition. Obese polycystic ovary syndrome (PCOS) is considered an independent risk factor for it. In this study, we report a case of successful pregnancy in an obese patient with PCOS combined with EFS and discuss the pathogenesis of EFS and optimal treatment strategies.</p><p><strong>Patient concerns: </strong>A 25-year-old woman presents with \"6 years of infertility without contraception.\"</p><p><strong>Diagnoses: </strong>Primary infertility, bilateral fallopian tube obstruction, PCOS, and EFS.</p><p><strong>Interventions: </strong>The patient underwent 2 cycles of controlled ovarian stimulation. In the first cycle, despite adequate ovarian stimulation, oocytes were not obtained and a diagnosis of EFS was made. In the second cycle, the following optimization measures were taken: the use of beinaglutide to help the patient lose weight and improve her blood glucose levels, supplementation with luteinizing hormone-active medications (e.g., Menotropins for injection), an increase in the dose of human chorionic gonadotropin, and the addition of growth hormone to improve the outcome of oocytes retrieval once the patient's blood glucose levels had stabilized.</p><p><strong>Outcomes: </strong>In the second cycle, 15 oocytes were successfully obtained, 13 oocytes of which were Metaphase II, resulting in the culture of 5 high-quality embryos. The patient had a successful pregnancy after frozen embryo transfer and was followed up to late-term pregnancy without abnormalities.</p><p><strong>Lessons: </strong>Multiple complex mechanisms may be involved in the development of EFS, and preconditioning and individualized treatment protocols are essential for improving outcomes in patients with EFS. Our treatment protocol provides some reference basis for the treatment of EFS.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 26","pages":"e43001"},"PeriodicalIF":1.4000,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212853/pdf/","citationCount":"0","resultStr":"{\"title\":\"Successful outcome of assisted reproductive technology in women with polycystic ovary syndrome combined with empty follicle syndrome: A case report.\",\"authors\":\"Danyang Guo, Lin Zhang, Xiaoxia Lin, Sha Tang, Bin Zhang, Linlin Ni\",\"doi\":\"10.1097/MD.0000000000043001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Rationale: </strong>Empty follicle syndrome (EFS) is a rare and difficult-to-treat condition. Obese polycystic ovary syndrome (PCOS) is considered an independent risk factor for it. In this study, we report a case of successful pregnancy in an obese patient with PCOS combined with EFS and discuss the pathogenesis of EFS and optimal treatment strategies.</p><p><strong>Patient concerns: </strong>A 25-year-old woman presents with \\\"6 years of infertility without contraception.\\\"</p><p><strong>Diagnoses: </strong>Primary infertility, bilateral fallopian tube obstruction, PCOS, and EFS.</p><p><strong>Interventions: </strong>The patient underwent 2 cycles of controlled ovarian stimulation. In the first cycle, despite adequate ovarian stimulation, oocytes were not obtained and a diagnosis of EFS was made. In the second cycle, the following optimization measures were taken: the use of beinaglutide to help the patient lose weight and improve her blood glucose levels, supplementation with luteinizing hormone-active medications (e.g., Menotropins for injection), an increase in the dose of human chorionic gonadotropin, and the addition of growth hormone to improve the outcome of oocytes retrieval once the patient's blood glucose levels had stabilized.</p><p><strong>Outcomes: </strong>In the second cycle, 15 oocytes were successfully obtained, 13 oocytes of which were Metaphase II, resulting in the culture of 5 high-quality embryos. The patient had a successful pregnancy after frozen embryo transfer and was followed up to late-term pregnancy without abnormalities.</p><p><strong>Lessons: </strong>Multiple complex mechanisms may be involved in the development of EFS, and preconditioning and individualized treatment protocols are essential for improving outcomes in patients with EFS. Our treatment protocol provides some reference basis for the treatment of EFS.</p>\",\"PeriodicalId\":18549,\"journal\":{\"name\":\"Medicine\",\"volume\":\"104 26\",\"pages\":\"e43001\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-06-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212853/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/MD.0000000000043001\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MD.0000000000043001","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Successful outcome of assisted reproductive technology in women with polycystic ovary syndrome combined with empty follicle syndrome: A case report.
Rationale: Empty follicle syndrome (EFS) is a rare and difficult-to-treat condition. Obese polycystic ovary syndrome (PCOS) is considered an independent risk factor for it. In this study, we report a case of successful pregnancy in an obese patient with PCOS combined with EFS and discuss the pathogenesis of EFS and optimal treatment strategies.
Patient concerns: A 25-year-old woman presents with "6 years of infertility without contraception."
Diagnoses: Primary infertility, bilateral fallopian tube obstruction, PCOS, and EFS.
Interventions: The patient underwent 2 cycles of controlled ovarian stimulation. In the first cycle, despite adequate ovarian stimulation, oocytes were not obtained and a diagnosis of EFS was made. In the second cycle, the following optimization measures were taken: the use of beinaglutide to help the patient lose weight and improve her blood glucose levels, supplementation with luteinizing hormone-active medications (e.g., Menotropins for injection), an increase in the dose of human chorionic gonadotropin, and the addition of growth hormone to improve the outcome of oocytes retrieval once the patient's blood glucose levels had stabilized.
Outcomes: In the second cycle, 15 oocytes were successfully obtained, 13 oocytes of which were Metaphase II, resulting in the culture of 5 high-quality embryos. The patient had a successful pregnancy after frozen embryo transfer and was followed up to late-term pregnancy without abnormalities.
Lessons: Multiple complex mechanisms may be involved in the development of EFS, and preconditioning and individualized treatment protocols are essential for improving outcomes in patients with EFS. Our treatment protocol provides some reference basis for the treatment of EFS.
期刊介绍:
Medicine is now a fully open access journal, providing authors with a distinctive new service offering continuous publication of original research across a broad spectrum of medical scientific disciplines and sub-specialties.
As an open access title, Medicine will continue to provide authors with an established, trusted platform for the publication of their work. To ensure the ongoing quality of Medicine’s content, the peer-review process will only accept content that is scientifically, technically and ethically sound, and in compliance with standard reporting guidelines.