咪唑吡啶融合异喹啉酮的多组分反应引发合成。

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Beilstein Journal of Organic Chemistry Pub Date : 2025-06-13 eCollection Date: 2025-01-01 DOI:10.3762/bjoc.21.92

Ashutosh Nath, John Mark Awad, Wei Zhang

引用次数: 0

摘要

提出了以groebke - blackburn - bienaym (GBB)为起始反应，n-酰化、分子内diols - alder （IMDA）、脱水重芳构化反应合成咪唑吡啶融合异喹啉酮的新合成路线。通过高斯计算分析取代基对IMDA反应的影响，了解反应机理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A multicomponent reaction-initiated synthesis of imidazopyridine-fused isoquinolinones.

A new synthetic route initiated with Groebke-Blackburn-Bienaymé (GBB) followed by N-acylation, intramolecular Diels-Alder (IMDA), and dehydrative re-aromatization reactions for the synthesis of imidazopyridine-fused isoquinolinones is developed. Gaussian computation analysis on the effect of the substitution groups for the IMDA reaction is performed to understand the reaction mechanism.

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来源期刊

Beilstein Journal of Organic Chemistry 化学-有机化学

CiteScore

4.90

自引率

3.70%

发文量

167

审稿时长

1.4 months

期刊介绍： The Beilstein Journal of Organic Chemistry is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in organic chemistry. The journal publishes high quality research and reviews in all areas of organic chemistry, including organic synthesis, organic reactions, natural product chemistry, structural investigations, supramolecular chemistry and chemical biology.