为执业外科病理学家导航中枢神经系统肿瘤的分子神经病理学。

IF 1.9 4区医学 Q2 PATHOLOGY

American journal of clinical pathology Pub Date : 2025-06-29 DOI:10.1093/ajcp/aqaf063

Brannon Broadfoot, Regina Kwon, Murat Gokden, Analiz Rodriguez, Kevin J Bielamowicz, Erika Santos Horta, J Stephen Nix

{"title":"为执业外科病理学家导航中枢神经系统肿瘤的分子神经病理学。","authors":"Brannon Broadfoot, Regina Kwon, Murat Gokden, Analiz Rodriguez, Kevin J Bielamowicz, Erika Santos Horta, J Stephen Nix","doi":"10.1093/ajcp/aqaf063","DOIUrl":null,"url":null,"abstract":"Objective: The practice of surgical neuropathology incorporates molecular results into diagnoses that already integrate histologic, radiologic, and clinical findings. Many surgical pathologists evaluate central nervous system (CNS) tumors without neuropathology board certification.Methods: This review describes key preanalytical, analytical, and postanalytical considerations for molecular testing and provides context for these considerations using frequently encountered CNS tumors. An overview of common molecular modalities, including limitations, is given, and pitfalls in interpretation are addressed.Conclusions: In summary, this review offers a practical reference for the diagnosis of CNS specimens in a general surgical pathology practice.","PeriodicalId":7506,"journal":{"name":"American journal of clinical pathology","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Navigating molecular neuropathology of CNS neoplasms for the practicing surgical pathologist.\",\"authors\":\"Brannon Broadfoot, Regina Kwon, Murat Gokden, Analiz Rodriguez, Kevin J Bielamowicz, Erika Santos Horta, J Stephen Nix\",\"doi\":\"10.1093/ajcp/aqaf063\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: The practice of surgical neuropathology incorporates molecular results into diagnoses that already integrate histologic, radiologic, and clinical findings. Many surgical pathologists evaluate central nervous system (CNS) tumors without neuropathology board certification.Methods: This review describes key preanalytical, analytical, and postanalytical considerations for molecular testing and provides context for these considerations using frequently encountered CNS tumors. An overview of common molecular modalities, including limitations, is given, and pitfalls in interpretation are addressed.Conclusions: In summary, this review offers a practical reference for the diagnosis of CNS specimens in a general surgical pathology practice.\",\"PeriodicalId\":7506,\"journal\":{\"name\":\"American journal of clinical pathology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-06-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of clinical pathology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/ajcp/aqaf063\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of clinical pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/ajcp/aqaf063","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PATHOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

目的：外科神经病理学的实践将分子结果纳入已经整合了组织学，放射学和临床表现的诊断中。许多外科病理学家评估中枢神经系统（CNS）肿瘤没有神经病理学委员会的认证。方法：本综述描述了分子检测的分析前、分析和分析后的关键考虑因素，并提供了这些考虑因素的背景。概述了常见的分子模式，包括局限性，给出了解释的陷阱。结论：本文综述为普通外科病理实践中中枢神经系统标本的诊断提供了实用参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Navigating molecular neuropathology of CNS neoplasms for the practicing surgical pathologist.

Objective: The practice of surgical neuropathology incorporates molecular results into diagnoses that already integrate histologic, radiologic, and clinical findings. Many surgical pathologists evaluate central nervous system (CNS) tumors without neuropathology board certification.

Methods: This review describes key preanalytical, analytical, and postanalytical considerations for molecular testing and provides context for these considerations using frequently encountered CNS tumors. An overview of common molecular modalities, including limitations, is given, and pitfalls in interpretation are addressed.

Conclusions: In summary, this review offers a practical reference for the diagnosis of CNS specimens in a general surgical pathology practice.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

American journal of clinical pathology 医学-病理学

CiteScore

7.70

自引率

2.90%

发文量

367

审稿时长

3-6 weeks

期刊介绍： The American Journal of Clinical Pathology (AJCP) is the official journal of the American Society for Clinical Pathology and the Academy of Clinical Laboratory Physicians and Scientists. It is a leading international journal for publication of articles concerning novel anatomic pathology and laboratory medicine observations on human disease. AJCP emphasizes articles that focus on the application of evolving technologies for the diagnosis and characterization of diseases and conditions, as well as those that have a direct link toward improving patient care.